矽尘相关性自身免疫病的研究进展

Research progress of silica-associated autoimmune diseases

长期二氧化硅粉尘暴露可引起矽肺,同时也引起自身免疫功能异常,可能导致自身免疫病,如类风湿性关节炎、系统性硬化症、系统性红斑狼疮、特发性炎症性肌病、抗中心粒细胞胞质抗体相关性血管炎等。矽肺、自身免疫病可以单独发生,也可以合并存在。本文对矽尘相关性自身免疫病的概念、流行病学、临床特征以及可能的作用机制进行综述,以期提高对疾病的认识,推动诊断标准和治疗方案的制定。

Silicosis is caused by long-term exposure to dust containing crystalline silica.However,silica exposure,which may lead to autoimmune dysfunction,is associated with autoimmune diseases such as rheumatoid arthritis,systemic sclerosis,systemic lupus erythematosus,idiopathic inflammatory myopathy and anti-central granulocyte cytoplasmic antibody associated vasculitis.With silica exposure autoimmune diseases may exist with or without silicosis.This article reviews recent research on silica-associated autoimmune diseases such as the concept,epidemiology,clinical characteristics and potential mechanisms to improve the understanding of the disease and promote the formulation of diagnostic criteria and treatment plans.