中药有效成分对乳腺癌细胞G2/M期调控的研究进展

Research Progress on G/M Arrest in Breast Cancer Cells by Active Compounds of Traditional Chinese Medicine

全球乳腺癌发病率逐年增加,在女性患恶性肿瘤的患者中,乳腺癌的病死率高居第1位。中医药在治疗乳腺癌的方面有着非常显著的作用,能够提高综合疗效,减轻患者的病痛,并能提高患者的生活质量,同时缓解不良反应,为人类健康做出巨大的贡献。中药及其有效成分可以通过诱导乳腺癌细胞周期阻滞、抑制乳腺癌细胞的侵袭、转移及逆转多药耐药等达到抗乳腺癌作用。中药有效成分阻滞乳腺癌细胞的周期效果极其明显,通过影响乳腺癌细胞周期的进程,诱导乳腺癌细胞周期阻滞,已经成为抗乳腺癌药物的一个新方法。经Gap-phase期,即DNA合成后期(G2期)过渡到Mitotic期,即有丝分裂期(M期)的检查点,G2/M检查点是乳腺癌细胞存活或死亡的关键决定点。多数中药的有效成分可以通过多种调节途径,影响乳腺癌细胞发生G2/M期阻滞,抑制乳腺癌细胞的增殖,达到抗乳腺癌作用。因此文章对近年来的国内外文献归纳,较系统地阐述G2/M期相关调控分子的研究进展,同时梳理了生物碱、多糖、萜类、黄酮类、皂苷类及其他中药有效成分诱导人乳腺癌细胞G2/M期阻滞的方式及途径等的研究。通过对不同中药的有效成分诱导乳腺癌细胞G2/M期阻滞研究成果的总结,综述中药有效成分抗乳腺癌细胞增殖机制的研究进展,探讨中药有效成分通过诱导乳腺癌细胞G2/M期阻滞抑制乳腺癌增殖的机制,为深入研究中药有效成分的抗乳腺癌机制提供科学依据。

The global incidence of breast cancer has increased year by year. Breast cancer has the highest mortality rate in female patients with malignant tumors. Traditional Chinese medicine(TCM)has made great contribution to health of human being,improving the overall curative effect,reducing the patients’ pain,improving the quality of life and alleviating adverse reactions in patients. TCM and its active compounds can inhibit the proliferation of breast cancer cells by inducing cell cycle arrest,invasion,metastasis and reversing multidrug resistance. The effect of the compounds in TCM is obvious on inducing the arrest of the breast cancer cells cycle. It ′s a novel method to fight against breast cancer by influencing the progress of the breast cancer cell cycle and inducing the cell cycle arrest in breast cancer cells. Lots of studies have shown that the G2/M phase checkpoint which transition from gap-phase(G2 phase)to mitotic phase(M phase)in the cell cycle is the key point for cell survival or death. Many antitumor drugs can inhibit the proliferation of tumor cells through the cell cycle arrest. We summarized the domestic and foreign literatures in recent years,and comprehensively explained the research progress on the related regulatory molecules in G2/M arrest. In addition,we summarized and sorted out the researches on the methods and ways of alkaloids,polysaccharides,terpenes,flavonoids,saponins and other active compounds of TCM in inducing the G2/M arrest of human breast cancer cells. By summarizing the active compounds of various Chinese medicines in inducing G2/M arrest of breast cancer cells,and reviewing the research progress on mechanism of active TCM compounds for inhibiting the proliferation of breast cancer cells,we will,in this paper,investigate the mechanism of active TCM compounds for inhibiting the proliferation of breast cancer cells through inducing G2/M arrest of human breast cancer cells,so as to provide a scientific basis for in-depth research on the anti-breast cancer mechanism of the active compounds in TCM.