中医药治疗迟发性性腺功能减退症的系统评价与Meta分析

Systematic Review and Meta-analysis of Effect of Traditional Chinese Medicine in Treating Late Onset Hyponatremia

目的:运用Meta分析方法系统评价中医药治疗迟发性性腺功能减退症(late onset hyponatremia,LOH)的临床疗效。方法:通过检索PubMed,Web of Science,中国知网数据库(CNKI),万方数据库(WanFang Data),维普全文期刊数据库(VIP),中国生物医学文献数据库(CBM)等,收集中医药治疗LOH的随机对照试验,由2名研究人员独立筛选文献、提取资料,选用Cochrance偏倚风险评估工具进行质量评估后,采用RevMan5.3.5软件进行Meta分析。结果:最终纳入9篇符合要求的文献,纳入患者739例。Meta分析结果显示,观察组在改善患者的体能/心血管评分[均方差(MD)=-1.42,95%可信空间(CI)(-2.39,-0.45),P=0.004],精神心理评分[MD=-0.74,95%CI(-1.26,-0.22),P=0.005]方面优于对照组,在改善性功能评分[MD=-0.68,95%CI(-1.38,-0.03),P=0.06],提高血清睾酮(TT)浓度[MD=-0.68,95%CI(-1.38,-0.03),P=0.06]及有效率[比值比(OR)=1.57,95%CI(0.64,3.88),P=0.33]方面,观察组与对照组之间的差异不具有统计学意义。结论:在治疗LOH时,中药与西药(十一酸睾酮)的疗效相当,且在改善患者体能/心血管评分、精神心理评分方面,中药优于西药。

Objective: The Meta-analysis was used to systematically evaluate the clinical efficacy of traditional Chinese medicine in treating Late onset hyponatremia(late onset hyponatremia,LOH). Method:Pubmed,Web of Science,China Knowledge Base Database(CNKI),Wanfang Database(WanFang),Weipu Full-text Periodical Database(VIP),Chinese Biomedical Literature Database(CBM)were retrieved to collect randomized controlled trials of traditional Chinese medicine(TCM)for treatment of LOH. Two researchers independently screened out the literatures,extracted the data,conducted quality assessment by Cochrance bias risk assessment tool,and made Meta-analysis by RevMan 5.3.5 software. Result: Nine eligible documents were finally included. Meta-analysis results showed that the test group was superior to the control group in improving patient’s physical fitness/cardiovascular score[mean deviation(MD)=-1.42,95% CI(-2.39,-0.45),P=0.004]and psycho-psychological score[MD=-0.74,95% CI(-1.26,-0.22),P=0.005],with no statistically significant difference between test group and control group in sexual function score[MD=-0.68,95% CI(-1.38,-0.03),P=0.06],serum testosterone(TT)concentration[MD=-0.68,95% CI(-1.38,-0.03),P=0.06] and effective rate[odds ratio(OR)=1.57,95% CI(0.64,3.88),P=0.33]. Conclusion: TCM is equivalent to western medicine(testosterone undecanoate)in the treatment of late onset hypogonadism,and better than western medicine in improving patients’ physical fitness/cardiovascular score and mental and psychological score.