基于相对质量常数的丹参饮片等级评价

Grade Evaluation of Salviae Miltiorrhizae Radix et Rhizoma Decoction Pieces Based on Relative Quality Constant

目的:建立传统性状评价和现代内在质量分析相结合的丹参饮片等级评价标准。方法:测定18批丹参饮片的外观性状参数(厚度、质量)和内在指标成分(丹参酮类与和丹酚酸B)含量,计算相对质量常数,并假设所测样品的百分质量常数最大值为100%,数值≥80%列为一等,≥50%且<80%列为二等,<50%列为三等。结果:18批丹参饮片的相对质量常数范围349~884。依据百分质量常数,18批样品成功分为3个等级。一等丹参饮片的相对质量常数≥707,包括样品ds5,ds8,ds14,约占总样本数的17%;二等丹参饮片相对质量常数≥442且<707,约占总样本数的61%;其余的饮片样品为三等,其相对质量常数均<442。结论:以相对质量常数法对丹参饮片进行等级评价克服了单一方法的片面性,评价结果能够客观、合理、科学地划分丹参饮片等级,可为其他饮片的等级标准建立提供参考。

Objective: To establish the grade evaluation standard of Salviae Miltiorrhizae Radix et Rhizoma decoction pieces combining traditional character evaluation and modern intrinsic quality analysis.Method: The appearance character parameters(thickness and weight) and contents of internal index components(tanshinones and salvianolic acid B)of 18 batches of Salviae Miltiorrhizae Radix et Rhizoma decoction pieces were determined,and the relative quality constant was calculated. The maximum value of the percentage quality constants of the tested samples was assumed to be 100%,the value ≥80% was classified as the first-class,≥50% and <80% as the second-class,<50% as the third-class. Result:The relative quality constants of 18 batches of Salviae Miltiorrhizae Radix et Rhizoma decoction pieces ranged from 349 to 884. According to the percentage quality constant,18 batches of samples were successfully divided into three grades. The relative quality constant of the first-class product was ≥707,including samples ds5,ds8 and ds14,accounting for about17% of the total number of samples. The relative quality constant of the second-class product was ≥442 and <707,accounting for about 61% of the total number of samples. the other samples were of the third-class,and their relative quality constants were all <442. Conclusion: The method of relative quality constant overcomes the one-sidedness of the single method in the grade evaluation of Salviae Miltiorrhizae Radix et Rhizoma decoction pieces,and the evaluation results can objectively,reasonably and scientifically classify the grade of the decoction pieces,which can provide reference for the establishment of the grade standard of other decoction pieces.