肠道菌群与支气管哮喘发病相关机制研究进展

Correlation of intestinal flora with pathogenesis of bronchial asthma

支气管哮喘是由多种细胞和细胞组分参与的气道慢性炎症性疾病。自"卫生假说"提出并随着哮喘发病机制研究的不断深入,肠道菌群与哮喘的相关性以及肠道菌群影响哮喘发病的相关机制成为研究热点。肠道菌群影响哮喘发病的机制复杂,尚未完全阐明,目前研究主要包括:肠道菌群通过影响机体免疫耐受、免疫细胞的分化成熟和组织特异性归巢,通过其代谢产物短链脂肪酸影响哮喘的发生、发展,应用益生菌调节肠道菌群预防和治疗哮喘等。本文就肠道菌群影响哮喘发病的相关机制及应用益生菌预防和治疗哮喘的研究进展作一综述。

Bronchial asthma is a chronic inflammatory disease of airway, involved in many kinds of cells and cell components. Since the "hygiene hypothesis" was put forward and with the deepening of the research on the pathogenesis of asthma, the correlation between the intestinal flora and asthma and the related mechanism of the intestinal flora affecting the pathogenesis of asthma have become a research hotspot. The mechanism of the intestinal flora affecting asthma is very complex and has not been fully elucidated. The current research mainly includes that the intestinal flora affects the occurrence and development of asthma by affecting immune tolerance, differentiation and maturation of immune cells, tissue-specific homing, and short chain fatty acids.At the same time, scholars began to explore the application of probiotics in regulating the intestinal flora to prevent and treat asthma. This paper reviews the research progress of the mechanism of the intestinal flora affecting asthma and the application of probiotics in the prevention and treatment of asthma.