清肺解毒汤联合比阿培南治疗肺部感染临床研究

Clinical Study on Qingfei Jiedu Tang Combined with Biapenem for Pulmonary Infection

目的:观察清肺解毒汤联合比阿培南对肺部感染患者肺部感染评分(CPIS)、血清降钙素原水平及氧合指数(PaO_(2)/FiO_(2))的影响。方法:选取肺部感染患者90例,按随机数字表法分为研究组和对照组各45例。对照组给予比阿培南治疗,研究组在对照组基础上给予清肺解毒汤治疗。比较2组临床疗效、治疗前后CPIS评分、血清降钙素原水平及血气指标,并统计治疗期间不良反应发生率。结果:研究组总有效率为95.56%,高于对照组88.89%(P<0.05)。治疗后,2组CPIS评分都较治疗前降低,且研究组CPIS评分明显低于对照组(P<0.05)。治疗后,2组血清降钙素原水平较治疗前降低,且研究组血清降钙素原水平低于对照组(P<0.05)。治疗后,2组动脉血氧分压(PaO_(2))、血氧饱和度(SaO_(2))及氧合指数(PaO_(2)/FiO_(2))均高于治疗前,且研究组PaO_(2)、SaO_(2)及PaO_(2)/FiO_(2)均显著高于对照组(P<0.05)。研究组不良反应发生率为4.44%,低于对照组17.78%(P<0.05)。结论:清肺解毒汤联合比阿培南可有效缓解肺部感染患者的症状,改善血气指标,提高临床疗效,且安全性高。

Objective:To observe the effect of Qingfei Jiedu tang combined with biapenem on Clinical Pulmonary Infection Scores(CPIS),serum procalcitonin levels and oxygenation indexes(PaO_(2)/FiO_(2))in patients with pulmonary infection.Methods:A total of 90 cases of patients with pulmonary infection were selected and divided into the study group and the control group according to the random number table method,45 cases in each group.The control group was treated with biapenem,and the study group was additionally treated with Qingfei Jiedu tang based on the treatment of the control group.CPIS scores,serum procalcitonin levels and blood gas indexes before and after treatment as well as the clinical effect in the two groups were observed;the incidence of adverse reactions during treatment was counted.Results:The total effective rate was 95.56%in the study group,higher than that of 88.89%in the control group(P<0.05).After treatment,CPIS scores in the two groups were decreased when compared with those before treatment,and CPIS score in the study group was significantly lower than that in the control group(P<0.05).After treatment,serum procalcitonin levels in the two groups were decreased when compared with those before treatment,and the level in the study group was lower than that in the control group(P<0.05).After treatment,partial pressure of arterial oxygen(PaO_(2)),blood oxygen saturation(SaO_(2))and oxygenation indexes(PaO_(2)/FiO_(2))in the two groups were higher than those before treatment,and the above indexes in the study group were significantly higher than those in the control group(P<0.05).The incidence of adverse reactions was 4.44%in the study group,lower than that of 17.78%in the control group(P<0.05).Conclusion:The therapy of Qingfei Jiedu tang combined with biapenem can effectively relieve the symptoms in patients with pulmonary infection,improve the blood gas indexes and enhance the clinical effect with high safety.