化痰通络汤联合针刺治疗脑卒中后偏瘫临床研究

Clinical Study on Huatan Tongluo Tang Combined with Acupuncture for Hemiplegia After Stroke

目的:观察化痰通络汤联合针刺治疗脑卒中后偏瘫的临床疗效及对患者血清白蛋白(Alb)、胶质纤维酸性蛋白(GFAP)及S-100β水平的影响。方法:纳入80例脑卒中后偏瘫患者,随机分为2组各40例。2组均给予常规对症治疗,对照组给予针刺治疗,观察组给予化痰通络汤联合针刺治疗,均连续治疗12周。比较2组临床疗效、治疗前后Fugl-Meyer运动功能评分法(FMA)评分、Barthel指数评分及血清Alb、GFAP、S-100β水平。结果:总有效率观察组为72.50%,对照组为47.50%,2组比较,差异有统计学意义(P<0.05)。治疗后,2组FMA及Barthel指数评分均较治疗前升高(P<0.05),观察组FMA及Barthel指数评分均高于对照组(P<0.05);2组血清Alb、GFAP和S-100β水平均较治疗前降低(P<0.05),观察组血清Alb、GFAP和S-100β水平均低于对照组(P<0.05)。结论:化痰通络汤联合针刺治疗脑卒中后偏瘫,可有效改善患者的运动功能,提高其生活自理能力,降低血清Alb、GFAP及S-100β水平。

Objective:To observe the clinical effect of Huatan Tongluo tang combined with acupuncture for hemiplegia after stroke and its effect on the levels of albumin(Alb),glial fibrillary acidic protein(GFAP)and S-100βin serum.Methods:A total of 80 cases of patients with hemiplegia after stroke were selected and divided into the two group,40 cases in each group.Both groups were given routine symptomatic treatment;the control group was additionally treated with acupuncture,and the observation group was additionally treated with Huatan Tongluo tang combined with acupuncture.Both groups were treated for 12 weeks.The scores of Fugl-Meyer Assessment(FMA)and Barthel index as well as the levels of Alb,GFAP and S-100βin serum before and after treatment and the clinical effect in the two groups were compared.Results:The total effective rate was 72.50%in the observation group and 47.50%in the control group,the difference being significant(P<0.05).After treatment,the scores of FMA and Barthel index in the two groups were increased when compared with those before treatment(P<0.05),and the scores in the observation group were higher than those in the control group(P<0.05).After treatment,the levels of Alb,GFAP and S-100βin serum in the two groups were decreased when compared with those before treatment(P<0.05),and the levels in the observation group were lower than those in the control group(P<0.05).Conclusion:The therapy of Huatan Tongluo tang combined with acupuncture for hemiplegia after stroke can improve the clinical effect,the motor function and the self-care ability of patients as well as reduce the levels of Alb,GFAP and S-100βin serum.