糖尿病肾病微炎症状态与“瘀”的关系探讨

Study on the Relationship Between Micro-Inflammation State of Diabetic Nephropathy and Blood Stasis

糖尿病肾病(DN)是糖尿病(DM)致死率最高的微血管并发症之一。"瘀"作为其发病的重要病机及致病因素已被认可,活血化瘀已成为其治疗的重要原则。从DN微炎症的产生机制、致炎因子的作用及活血化瘀药物对于这种免疫性炎症的治疗作用入手,发现二者密切相关,即现代医学中的DN微炎症状态,可能属于DN中医病机"瘀"的一部分。

Diabetic nephropathy(DN)is one of the microvascular complications with the highest lethality rate in diabetes mellitus(DM)."Blood stasis"has been recognized as its important pathogenesis and pathogenic factor,and activating blood and resolving stasis has become the important principle of its treatment.Starting from the production mechanism of DN micro-inflammation,the role of inflammatory factors and the curative effect of drugs for activating blood and resolving stasis on the immunological inflammation,it was found that the relationship between micro-inflammation state of diabetic nephropathy and blood stasis were closely related,that is,the DN micro-inflammation state in modern medicine may be part of"blood stasis",the Chinese medicine pathogenesis of DN.