中国南海海绵Aaptos suberitoides的化学成分

Study on the chemical constituents of sponge Aaptos suberitoides from the South China Sea

目的研究中国南海海绵Aaptos suberitoides中化学成分。方法运用薄层色谱、Sephadex LH-20凝胶色谱、硅胶色谱、半制备高效液相各种色谱手段对化合物进行分离纯化。利用核磁共振、质谱等波谱学手段,并结合其他理化性质及文献数据鉴定化合物的结构。结果从海绵Aaptos suberitoides的甲醇粗提取物中分离鉴定了7个单体化合物,分别为3-(methylamino)demethyl(oxy)aaptamnie、aaptamine、尿嘧啶、胸腺嘧啶、环(脯-丝)二肽cyclo(Pro-Ser)、环(脯-苏)二肽cyclo(Pro-Thr)、脱氧胸腺嘧啶核苷。结论化合物aaptamine、环(脯-丝)二肽cyclo(Pro-Ser)、环(脯-苏)二肽cyclo(Pro-Thr)为首次从本属海绵中分离得到。

Objective To investigate the chemical constituents of sponge Aaptos Suberitodes.Methods The compounds were isolated and purified by TLC,Sephadex LH-20 column,sillica gel column chromatography and semi-preparative HPLC.Their chemical structures were identified by NMR,MS and comparison with the data of literatures.Results From the CH3OH extract of Aaptos suberitoides,seven compounds were isolated and their structures were determined as 3-(methylamino)demethyl(oxy)aaptamnie,aaptamine,uracil,thymine,cyclo(Pro-Ser),cyclo(Pro-Thr)and thymine nuleoside.Conclusion Aaptamine,cyclo(Pro-Ser)and cyclo(Pro-Thr)were isolated from the genus Aaptos for the first time.