达格列净片致正常血糖酮症2例分析

Two Cases of Euglycemic Diabetic Ketosis Induced by Dapagliflozin Tablets

目的提高医务人员对达格列净片导致正常血糖酮症的警惕,为安全使用达格列净片提供参考。方法分析2例由达格列净片导致正常血糖酮症患者的诊疗经过,结合国内外文献分析,探讨达格列净片导致正常血糖酮症的发生情况以及危险因素。结果2例有糖尿病酮症病史的患者分别在使用达格列净片52 d和18 d后出现正常血糖酮症,立即停用达格列净片并予胰岛素治疗,患者酮体转阴。结论应重视达格列净片导致正常血糖酮症的风险,特别是在既往有糖尿病酮症病史患者中的使用风险。

Objective To remind medical staff to be more vigilant about Dapagliflozin tablets-induced euglycemic diabetic ketosis,and provide reference for safe use of Dapagliflozin tablets.Methods The process of diagnosis and treatment of 2 patients with euglycemic diabetic ketosis caused by Dapagliflozin tablets was analyzed,and the incidence and related risk factors were analyzed based on domestic and foreign literature.Results Two patients with a history of diabetic ketosis developed euglycemic diabetic ketosis 52 and 18 days after taking Dapagliflozin tablets,respectively.Dapagliflozin tablets were discontinued immediately and insulin therapy was given.The ketone bodies turned negative.Conclusion Clinicians should be alert to the risk of euglycemic diabetic ketosis induced by Dapagliflozin tablets,especially in patients with a history of diabetic ketosis.