碳酸锂抗躁狂症的临床应用进展及不良反应分析

Clinical Application and Adverse Reactions of Lithium Carbonate in Anti-mania

目的总结碳酸锂抗躁狂症的临床应用及安全性研究进展,为临床合理用药提供参考。方法对国内外有关碳酸锂临床应用及安全性的文献进行综述及分析比较。结果碳酸锂的治疗量与中毒量比较接近,易对神经系统、泌尿系统、内分泌系统、胃肠道系统等造成损害,甚至导致锂中毒;目前临床上多用碳酸锂联合其他抗精神病药物治疗躁狂症,且治疗期间往往需多次检测血锂浓度以保障用药安全性。结论碳酸锂仍是国内外预防及治疗躁狂症的一线药物,建议在临床用药中考虑与其他抗精神病药物联合应用,还应重视其不良反应的发生,根据血锂浓度及个体差异,促进合理用药。

Objective To summarize the research progress in clinical application and safety of lithium carbonate used for mania,and to provide reference for clinical rational drug use.Methods Domestic and foreign literature on the clinical application and safety of lithium carbonate was reviewed for analysis and comparison.Results The treatment dose of lithium carbonate is close to the toxic dose,which is likely to cause damage to the nervous system,urinary system,endocrine system,gastrointestinal system,and even lithium poisoning.Lithium carbonate is currently often used in combination with other antipsychotic drugs in the treatment of mania,and the blood lithium concentration has to be detected many times during the treatment to ensure the safety of medication.Conclusion Lithium carbonate remains the first-line drug for the prevention and treatment of mania at home and abroad.It is suggested that the combination of lithium carbonate with other antipsychotics be considered in clinical medication.Attention should be paid to the occurrence of adverse reactions,and the rational use of drugs should be promoted according to the blood lithium concentration and individual differences.