中性粒细胞胞外诱捕网对缺血性脑卒中的影响及中药干预研究进展

Effect of neutrophil extracellular traps on ischemic stroke and intervention of traditional Chinese medicine

缺血性脑卒中是我国成年人致死和致残的首位原因,近年发现中性粒细胞胞外诱捕网(NETs)在脑卒中发生发展中起着重要作用。该文查阅自NETs发现十余年的文献,从NETs的组成、对脑卒中的影响、干预靶标以及中药对NETs的影响等方面归纳总结,发现:①NETs是引起卒中后脑损伤的重要因素;②血小板、酰基精氨酸脱亚胺酶4、活性氧、组蛋白等都可以作为调控NETs形成的靶标;③中药靶向NETs治疗脑卒中鲜有报道,目前的研究主要针对NETs的主要组成成分中性粒细胞和诱导成分血小板进行,这将拓宽中药抗炎的研究思路。该文旨在全面地了解NETs在脑卒中疾病的研究现状,以期为脑卒中的治疗及药物研发提供新的思路。

Ischemic stroke is the leading cause of death and disability in adults in China.Recent studies have shown that neutrophil extracellular traps play a crucial role in occurrence and development of ischemic stroke.This paper reviewed the literatures on NETs since the discovery of NETs more than a decade ago,and summarized the composition of NETs,the effects of NETs on stroke,the intervention targets of NETs,and the effects of traditional Chinese medicine on NETs.NETs are an important cause of brain injury after stroke.Platelets,peptidylarginine deiminase 4,reactive oxygen species and histones are the targets to regulate NET formation in stroke.There are few researches on traditional Chinese medicine targeting NETs for stroke.Studies on the intervention of traditional Chinese medicine mainly target on neutrophils,which are the main components of NETs,and platelets,which induce the formation of NETs.The paper provided a comprehensive overview of current studies of NETs in ischemic stroke,so as to provide new ideas for the treatment and drug development of ischemic stroke.