鱼腥草芩蓝合剂联合磷酸奥司他韦颗粒对早期流感样儿童的疗效研究

Effect of Yuxingcao Qinlan Mixture and Oseltamivir Phosphate on Early Influenza-like Children

目的:探讨鱼腥草芩蓝合剂、磷酸奥司他韦联合治疗早期流感样儿童的实际效果。方法:纳入2019年6-12月笔者所在医院收治的早期流感样患儿作为临床研究的对象,最终纳入103例,使用洗牌法随机分为观察组与对照组。对照组使用鱼腥草芩蓝合剂治疗,观察组加用磷酸奥司他韦颗粒治疗。观察两组患儿退热时间、症状评分变化情况,各症状缓解时间、住院时间、住院费用及不良反应发生情况。结果:观察组患儿用药后1、5 d症状评分显著低于对照组(P<0.05);两组患儿用药后10 d症状评分对比差异无统计学意义(P>0.05);观察组患儿各症状缓解时间显著早于对照组(P<0.01);观察组患儿住院时间显著短于对照组(P<0.01);观察组患儿住院费用显著少于对照组(P<0.01);两组患儿不良反应发生率比较差异无统计学意义(P>0.05)。结论:鱼腥草芩蓝合剂联合磷酸奥司他韦颗粒治疗早期流感样儿童效果确切,患儿症状缓解更快,转院时间段,家属经济负担更小,且并未存在严重不良反应,安全性较高,在临床中具备进一步应用价值。

Objective:To explore the practical effect of the combination of Yuxingcao Qinlan Mixture and Oseltamivir Phosphate on early influenza-like children.Method:The early influenza-like children admitted to our hospital from June to December 2019 were included as clinical research objects,and 103 cases were finally included.They were randomly divided into the observation group and the control group by using the shuffling method.The control group was treated with Yuxingcao Qinlan Mixture,on this basis,the observation group was treated with Oseltamivir Phosphate Granules.Observed the changes of fever time and symptom scores,the relief time of each symptom,hospitalization time,hospitalization cost and adverse reactions in the two groups of children.Result:The symptom scores of the children in the observation group were significantly lower than those of the control group at 1 and 5 days after treatment (P<0.05);there was no difference in the symptom scores at 10 days after the treatment between the two groups of patients (P>0.05);the symptoms of the observation group were significantly earlier than that in the control group (P<0.01);the hospital stay of the observation group was significantly shorter than the control group (P<0.01);the hospitalization cost of the observation group was significantly less than the control group (P<0.01);the incidence of adverse reactions in the two groups has no significant difference (P>0.05).Conclusion:Yuxingcao Qinlan Mixture combined with Oseltamivir Phosphate is effective in the treatment of early influenza-like children.The symptoms of the children are relieved faster.The time of transfer to the hospital is lower.The economic burden of the family members is smaller,and there are no serious adverse reactions.higher safety,with further application value in clinical.