丁苯酞对脑缺血患者的临床疗效及对血清炎症因子的影响

Clinical Curative Effect of Butyl Phthalide in Patients with Cerebral Ischemia and the Effect on Serum Inflammatory Factors

目的:探究丁苯酞对脑缺血患者的临床疗效及对血清炎性因子的影响。方法:选择2018年3月-2020年3月本院接诊的96例脑缺血急诊溶栓患者作为研究对象,根据治疗药物不同分为观察组(n=48)和对照组(n=48)。对照组给予常规药物治疗,观察组加用丁苯酞治疗。比较两组治疗后临床疗效、美国国立卫生研究院卒中量表(NIHSS)、Barthel指数及血清超敏C反应蛋白(hs-CRP)、白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)、正五聚蛋白3(PTX-3)水平。结果:治疗后观察组临床总有效率93.75%,高于对照组的77.08%(P<0.05);两组患者治疗前NIHSS评分、Barthel指数比较差异无统计学意义(P>0.05),治疗14 d,两组NIHSS评分明显下降,Barthel指数评分显著升高,且观察组NIHSS评分显著低于对照组,Barthel指数显著高于对照组(P<0.05);治疗前两组血清hs-CRP、IL-6、TNF-α、PTX-3水平比较差异无统计学意义(P>0.05);治疗14 d,两组血清hs-CRP、IL-6、TNF-α、PTX-3水平显著下降,且观察组显著低于对照组(P<0.05)。结论:丁苯酞对脑缺血患者临床疗效显著,可明显改善血清炎性因子水平,促进患者神经功能和自理能力恢复。

Objective:To explore the clinical curative effect of the Butyl Phthalide in patients with cerebral ischemia and the effect on serum inflammatory factors.Method:From March 2018 to March 2020,96 patients with cerebral ischemia emergency thrombolysis in our hospital departments were chosen as the research objects,according to different therapeutic drugs,they were divided into the observation group (n=48) and the control group (n=48).The control group was given conventional drug treatment,and the observation group was given Butyl Phthalide treatment.The clinical effects,national institutes of health stroke scale (NIHSS) scores,Barthel index,serum hypersensitive C-reactive protein (hs-CRP) and interleukin 6 (IL-6),tumor necrosis factor alpha (TNF-α),Pentraxin-3 (PTX-3) level were compared between the two groups.Result:The total effective rate of the observation group was 93.75%,which was higher than 77.08% of the control group (P<0.05).There were no significant differences in NIHSS score and Barthel index between the two groups before treatment (P>0.05).After 14 d of treatment,the NIHSS score of the two groups decreased significantly,and NIHSS of the observation group was significantly lower than that of the control group,and Barthel index of the observation group was significantly higher than that of the control group (P<0.05).There were no significant difference in serum hs-CRP,IL-6,TNF-α and PTX-3 between the two groups before treatment (P>0.05).After 14 d of treatment,serum hs-CRP,IL-6,TNF-α and PTX-3 levels in the two groups were significantly decreased,and those in the observation group were significantly lower than those in the control group (P<0.05).Conclusion:Butyl Phthalide has a significant clinical effect on cerebral ischemia patients,can significantly improve the level of serum inflammatory factors,promote the recovery of neurological function and behavioral ability.