依折麦布联合氨氯地平阿托伐他汀钙片治疗高血压合并冠心病患者的效果

Effect of Ezetimibe Combined with Amlodipine Besylate Atorvastatin Calcium in the Treatment of Patients with Hypertension Complicated with Coronary Heart Disease

目的:探讨依折麦布联合氨氯地平阿托伐他汀钙片对高血压合并冠心病患者血脂、血管内皮功能及炎症因子的影响。方法:选取2019年4月-2020年1月本院收治的高血压合并冠心病患者90例,随机将其分为对照组(给予氨氯地平阿托伐他汀钙片治疗)与联合组(给予依折麦布联合氨氯地平阿托伐他汀钙片治疗),各45例。比较两组治疗总有效率、治疗前后血脂水平、血管内皮功能指标及炎症因子水平及治疗期间不良反应发生情况。结果:联合组治疗总有效率97.78%(44/45)明显高于对照组77.78%(35/45),差异有统计学意义(P<0.05)。治疗后联合组血清甘油三酯、总胆固醇、低密度脂蛋白胆固醇水平均明显低于对照组,血清高密度脂蛋白胆固醇水平明显高于对照组(P<0.05)。治疗后联合组血清内皮素-1水平明显低于对照组,血清一氧化氮、肱动脉内皮依赖性血管舒张功能均明显高于对照组(P<0.05)。治疗后联合组血清白细胞介素-6、C反应蛋白、肿瘤坏死因子-α水平均明显低于对照组(P<0.05)。联合组不良反应总发生率为26.67%(12/45),略高于对照组的24.44%(11/45),差异无统计学意义(P>0.05)。结论:对高血压合并冠心病患者给予依折麦布联合氨氯地平阿托伐他汀钙片治疗效果较好,可明显降脂及调节血管内皮功能,且能有效抑制机体炎症反应,值得推广应用。

Objective:To discuss the influence of Ezetimibe combined with Amlodipine Besylate Atorvastatin Calcium on blood lipid,vascular endothelial function and inflammatory factors in patients with hypertension complicated with coronary heart disease.Method:A total of 90 patients with hypertension complicated with coronary heart disease in our hospital from April 2019 to January 2020 were selected,which were randomly divided into the control group(treated with Amlodipine Besylate Atorvastatin Calcium)and the combination group(treated with Ezetimibe combined with Amlodipine Besylate Atorvastatin Calcium),45 cases in each group.Recorded and compared the total effective rate,blood lipid level,vascular endothelial function index and inflammatory factor levels before and after treatment and the incidence of adverse reactions during the treatment.Result:The total effective rate of the combined group 97.78%(44/45)was significantly higher than 77.78%(35/45)of the control group,the difference was statistically significant(P<0.05).After treatment,the serum triglyceride,total cholesterol,low-density lipoprotein cholesterol levels of the combined group were significantly lower than those of the control group,while the serum high density lipoprotein cholesterol level of the combined group was significantly higher than that of the control group(P<0.05).After treatment,the serum endothelin-1 level of the combined group was significantly lower than that of the control group,while the serum nitric oxide,flow-mediated dilation of the combined group were significantly higher than those of the control group(P<0.05).After treatment,the serum interleukin-6,C reaction protein,tumor necrosis factor-ɑlevels of the combined group were significantly lower than those of the control group(P<0.05).The total incidence of adverse reactions of the combination group was 26.67%(12/45),which was slightly higher than 24.44%(11/45)of the control group,there was no significant difference(P>0.05).Conclusion:Ezetimibe combined with Amlodipine Besylate Atorvastatin Calcium is effective in the treatment of hypertension complicated with coronary heart disease,which can significantly reduce blood lipid and regulate vascular endothelial function,and can effectively inhibit the inflammatory reaction of the body,which is worthy of promotion and application.