化瘀消癥方在子宫腺肌病合并不孕患者GnRH-a治疗后窗口期应用的临床研究

A Study on Clinical Effect of Huayu Xiaozheng Prescription(化疾消癥方)of Adenomyosis with Infertility in the Window Period after GnRH-a Treatment

目的:研究化瘀消癥方在子宫腺肌病合并不孕患者Gn RH-a治疗后窗口期应用的临床疗效。方法:将60例子宫腺肌病合并不孕Gn RH-a治疗后窗口期的患者随机分为治疗组及对照组,各30例。对照组予尿促卵泡素+绒促性素+来曲唑治疗,治疗组在对照组的基础上加化瘀消癥方。结果:两组患者治疗前后子宫体积、内膜厚度、子宫动脉搏动指数(PI)、阻力指数(RI)、收缩期血流速度峰值(PSV)比较,差异均有统计学意义(P<0.05);血清CA125值比较,差异无统计学意义(P>0.05)。治疗后组间比较,治疗组患者子宫体积、内膜厚度、PI、RI、PSV均优于对照组,差异均有统计学意义(P<0.05),血清CA125值比较,差异无统计学意义(P>0.05)。治疗组妊娠率为60.00%(18/30),高于对照组的33.33%(10/30),差异有统计学意义(P<0.05)。结论:子宫腺肌病合并不孕Gn RH-a治疗后窗口期联合化瘀消癥方可改善子宫动脉血流情况,增加内膜厚度,提高宫内自然妊娠率。

Objective:To study the clinical effect of Huayu Xiaozheng Prescription in the treatment of adenomyosis with infertility in the window period after GnRH-a treatment.Methods:Totally 60 patients were randomly divided into treatment and control groups.Patients were given urofollicle stimulating hormone+chorionic gonadotropin+letrozole in control group.Patients in treatment group were treated by Huyu Xiaozheng Prescription on the basis of the control group.Results:There were significant differences in uterine volume,endometrial thickness,uterine artery pulsation index(PI),resistance index(RI)and peak systolic blood flow velocity(PSV)before and after treatment in the two groups(P<0.05).There was no significant difference in serum CA125 before and after treatment(P>0.05).After treatment,the treatment group showed better uterine volume,endometrial thickness,PI,RI and PSV than the control group,and the difference was statistically significant(P<0.05).There was no significant difference in serum CA125 between the two groups(P>0.05).The pregnancy rate was 60.00%(18/30)in the treatment group and 33.33%(10/30)in control group.The treatment group showed higher pregnancy rate than control group(P<0.05).Conclusion:Huayu Xiaozheng Prescription can improve the blood flow of uterine artery,increase the thickness of endometrium,and enhance the rate of intrauterine natural pregnancy in the window period after GnRH-a treatment for adenomyosis with infertility.