婴儿纤维性错构瘤

A case of fibrous hamartoma of infancy

报告1例婴儿纤维性错构瘤。患儿男,4岁。左足底皮下肿物2年。皮肤科检查:左足底一2.0 cm×1.5 cm×1.0 cm皮下结节,中等硬度,界限较模糊,活动度差,表面皮肤正常。手术切除肿物,肿物呈淡黄色桑葚状,无包膜,与周围组织无明显粘连。皮损组织病理检查:肿瘤由纤维组织、成熟的脂肪组织及原始间叶细胞组成,3种成分混杂交错,彼此间有明显的界限。免疫组化:肿瘤细胞CD34、平滑肌肌动蛋白(SMA)、desmin、S-100蛋白及增殖核抗原(Ki-67)均阴性;成熟脂肪细胞S-100蛋白阳性。诊断:婴儿纤维性错构瘤。

A case of fibrous hamartoma of infancy is reported.A 4-year-old boy presented with a subcutaneous nodule on the left planta pedis for 2 years.Physical examination revealed a 2.0 cm×1.5 cm×1.0 cm single,subcutaneous nodule with unclear boundaries,medium hardness,and poor mobility.The skin on the surface of the nodule was normal.Complete excision of the nodule was done.One yellowish mulberry-shaped tumor without amicula was seen in the operation,and it had no obvious adhesion with the surrounding tissue.Histopathological examination revealed the tumor consisted of fibrous tissue,mature fat tissue and immature mesenchymal cells.The three components were mixed and interlaced with distinct boundaries.Immunohistochemistry showed the neoplastic cells were negative for CD34,SMA,desmin,S-100 protein and Ki-67,while mature adipocytes were positive for S-100 protein.The diagnosis of fibrous hamartoma of infancy was made.