蜂胶抗肿瘤功效成分研究

Study on the antitumor bioactive constituents of Chinese propolis

为确定中国杨属型蜂胶的抗肿瘤功效成分,通过SRB法分别测定逐级洗脱的蜂胶乙酸乙酯提取物中分离得到的8段组分对8种不同的肿瘤细胞存活率的影响.结果表明,蜂胶乙酸乙酯提取物中的8段组分对8种肿瘤细胞增殖的抑制功效不同.蜂胶的抗肿瘤功效成分十分复杂,很可能是多种功效成分协同作用的结果,而且蜂胶中黄酮类及酯类物质的含量和种类决定蜂胶的抗肿瘤功效.

To discover the bioactive constituents of Chinese propolis on antitumor activity,SRB method was used to test the cell viability of 8 subfractions eluted from ethyl acetate extracted Chinese propolis on 8 different tumor cells,respectively.Results showed that 8 subfractions had different antitumor activities on 8 different tumor cells.The antitumor bioactive components of Chinese propolis were very complex and it might be a synergism activity of various different bioactive components.Furthermore,the kinds and content of flavonoids and esters were the determinants for propolis on antitumor activity.