摘要
将氢化诺卜基二甲基胺分别与3种α,ω-二氯代烷反应制备了3种新型含氢化诺卜基的双子季铵盐:四亚甲基-1,4-双(氢化诺卜基二甲基氯化铵)(2a)、五亚甲基-1,5-双(氢化诺卜基二甲基氯化铵)(2b)和六亚甲基-1,6-双(氢化诺卜基二甲基氯化铵)(2c)。对其结构进行NMR和MS表征,并采用菌丝生长速率法测定了这3种化合物对9种植物病原菌的抑菌活性,结果表明:3种化合物对所试植物病原菌均有优良的抑菌活性,其中化合物2c的抑制效果最好,其在质量浓度12.5~200 mg/L时对枇杷炭疽病菌、松枯梢病病原菌、七叶树壳孢菌、烟草黑胫病菌和西瓜枯萎病菌的抑制率都大大高于相同质量浓度的百菌清。
Three novel hydronopylgemini quaternary ammonium salts,namely tetramethylene-1,4-bis-(hydronopyl dimethyl ammonium chloride)(2a),pentamethylene-1,5-bis-(hydronopyl dimethyl ammonium chloride)(2b)and hexamethylene-1,6-bis-(hydronopyl dimethyl ammonium chloride)(2c)were synthesized from hydronopyl dimethyl amine and threeα,ω-dibromoalkanes,respectively.Their structures were characterized by NMR and MS.The inhibition activities of the target compounds against nine plant pathogens were evaluated by mycelium growth rate method.The results showed that the three compounds had excellent antifungal activity against the tested plant pathogens,and compound 2c had the best inhibitory effect,in which its inhibitory rates on Colletotrichum acutatu,Sphaeropsis sapinea,Fusicoccum aesuli,Phytophthora parasitica var.Nicotianae and Fusarium oxysporum were much higher than that of chlorothalonil at all concentrations(12.5-200 mg/L)tested.
作者
冯雪贞
肖转泉
范国荣
王宗德
FENG Xuezhen;XIAO Zhuanquan;FAN Guorong;WANG Zongde(College of Forestry,Jiangxi Agricultural University,East China Woody Fragrance and Flavor Engineering Research Center of National Forestry and Grassland Administration,Nanchang 330045,China;College of Chemistry and Chemical Engineering,Jiangxi Normal University,Nanchang 330027,China)
出处
《生物质化学工程》
CAS
2021年第2期45-49,共5页
Biomass Chemical Engineering
基金
国家自然科学基金资助项目(31660178)
江西省重点研发计划重点项目(20192ACB60011)。
关键词
氢化诺卜基
双子季铵盐
合成
抑菌活性
hydronopyl
gemini quaternary ammonium salt
synthesis
antifungal activity