人肝细粒棘球蚴病致病的研究进展

Research progress on the pathogenesis of human hepatic echinococcosis

人肝细粒棘球蚴病是棘球蚴绦虫引起的一种人兽共患寄生虫病,也称肝包虫病,细粒棘球蚴的致病机制主要是对器官挤压,其次是细粒棘球蚴分泌的毒素对人体的毒性反应。目前,肝包虫病主要通过手术进行根治治疗。随着微创手术及精准手术标准的引用,腹腔镜手术治疗肝包虫病得到了长足的发展,本文将从腹腔镜肝包虫病适应症的选择、腹腔镜手术治疗肝包虫病的优势与劣势、腹腔镜手术与其他手术方式治疗效果对比、腹腔镜治疗肝包虫病的新技术、新方法、目前腹腔镜手术治疗肝包虫病存在的问题等方面作一综述。

Human hepatic echinococcosis is a zoonotic parasitic disease caused by echinococcus parasites.The pathogenic mechanism of Echinococcus granulosus is mainly the extrusion of organs,followed by a reaction to the toxin secreted by E.granulosus into the human body.Radical surgical resection is currently the primary treatment option for hepatic echinococcosis.With the application of minimally invasive surgery and precision surgery standards,laparoscopic surgery has made considerable progress in the treatment of hepatic hydatid disease.This article reviews the current status of laparoscopic treatment of hepatic echinococcosis from the following aspects:the indications of hepatic echinococcosis;the advantages and disadvantages of laparoscopic surgery in therapy for hepatic hydatid disease;new technologies and methods;indications,contraindications,efficacy,and complications;and the difference between this method and other surgical approaches.