前庭性偏头痛患者基于体素的脑灰质体积研究

Voxel-based gray matter volume study in patients with vestibular migraine

目的采用基于体素的形态分析法(voxel-based morphological analysis,VBM)分析前庭性偏头痛(vestibular migraine,VM)患者大脑灰质体积改变区域,以期提供临床病理生理方面的新思路。材料与方法严格按照纳入标准及排除标准,招募了17例VM患者及20例健康对照组。所有受试者均接受头部三维T1加权像磁共振成像(magnetic resonance imaging,MRI)扫描,采用VBM技术对两组大脑灰质体积进行比较,探索与该疾病病理生理相关的局部灰质变化。结果与健康对照组相比,VM患者小脑、小脑蚓部、前扣带回、眶部额中回、右颞横回,枕颞内侧回、右侧角回体积减少(P<0.001,FEW校正)。结论VM患者存在多个疼痛伤害性和多感觉整合性脑区域的灰质体积异常,出现体积改变的中枢性脑区域可能参与了该疾病的病理生理机制。

Objective:Voxel-based morphological analysis(VBM)was used to analyze the areas of gray matter changes in patients with vestibular migraine(VM),in order to provide new ideas in clinical pathophysiology.Materials and Methods:In strict accordance with the inclusion and exclusion criteria,17 VM patients and 20 healthy controls were recruited.All subjects underwent three-dimensional T1-weighted image magnetic resonance(MRI)scans of the head.VBM was used to compare the brain gray matter volume of the two groups to explore local gray matter changes related to the pathophysiology of the disease.Results:Compared with the healthy control group,the gray matter volume of cerebellum,cerebellar vermis,anterior cingulate gyrus,middle orbital frontal gyrus,right temporal transverse gyrus,fusiform gyrus,right angular gyrus of VM patients decreased in VM group(P<0.001,FEW correction).Conclusion:VM patients have multiple pain nociceptive and multisensory integrated brain regions with GM abnormalities.The central brain regions with volume changes may be involved in the pathophysiological mechanism of the disease.