代谢综合征与2 型糖尿病病人慢性肾脏病的相关性分析

The correlation between metabolic syndrome and chronic kidney disease in patients with type 2 diabetes mellitus

目的探讨2型糖尿病病人代谢综合征和慢性肾脏病发生的相关性。方法研究纳入武汉市新洲区人民医院内分泌科2016年1月至2018年12月期间住院的2129例2型糖尿病病人,根据是否合并代谢综合征分为合并代谢综合征组和未合并代谢综合征组,分析合并和未合并代谢综合征的2型糖尿病病人中慢性肾脏病的患病率,探讨代谢综合征与慢性肾脏病的发生之间的关系。结果在合并代谢综合征的2型糖尿病病人中,年龄、体质量指数、腰围和尿酸的水平高于未合并代谢综合征的病人(P<0.05)。合并代谢综合征的2型糖尿病病人慢性肾脏病的患病率高于未合并代谢综合征的病人(16.05%比4.88%,χ^(2)=46.523,P<0.001)。单因素和多因素logistic回归分析提示,高龄、女性、高血肌酐、代谢综合征是2型糖尿病病人发生慢性肾脏病的独立危险因素(P<0.05,OR>1)。结论在2型糖尿病病人中,代谢综合征与慢性肾脏病的发生密切相关,代谢综合征可增加2型糖尿病病人并发慢性肾脏病的发生风险。

Objective To investigate the correlation between metabolic syndrome and chronic kidney disease in patients with type 2 diabetes mellitus.Methods A total of 2129 hospitalized patients diagnosed with type 2 diabetes mellitus in the department of endocri⁃nology of Xinzhou District People's Hospital from January 2016 to December 2018 were enrolled in this study.According to the coexis⁃tence of metabolic syndrome or not,patients were divided into the metabolic syndrome group and the non-metabolic syndrome group.The prevalence of chronic kidney disease in patients with type 2 diabetes mellitus between two groups was investigated and the correla⁃tion between metabolic syndrome and chronic kidney disease was analyzed.Results The average age,body mass index,waist circumference and uric acid levels in type 2 diabetes mellitus patients with metabolic syndrome were higher than those without metabolic syn⁃drome(P<0.05).The prevalence of chronic kidney disease in type 2 diabetic patients with metabolic syndrome was higher than that in patients without metabolic syndrome(16.05%vs.4.88%,χ^(2)=46.523,P<0.001).Univariate and multivariate logistic regression analy⁃sis showed that older age,female,higher levels of creatinine and metabolic syndrome were independent risk factors for chronic kidney disease in type 2 diabetic patients(P<0.05,OR>1).Conclusions Metabolic syndrome is closely related to the occurrence of chron⁃ic kidney disease in patients with type 2 diabetes mellitus.Metabolic syndrome could increase the risk of chronic kidney disease in pa⁃tients with type 2 diabetes mellitus.