膝骨关节炎患者血清IL-2、IL-6与血管内皮生长因子的相关性

Correlation between serum IL-2,IL-6 and vascular endothelial growth factor in patients with knee osteoarthritis

目的探讨膝骨关节炎患者血清炎性因子与血管形成相关因子(VEGF)的关系。方法选择2015年1月至2017年1月南方医科大学附属南海医院关节外科收治的36例膝骨关节炎患者作为观察组,其中Kellgren-LawrenceⅡ级13例、Ⅲ级14例、Ⅳ级9例,另选择同期体检健康者36例作为对照组,检测并比较两组受试者的血清白细胞介素-2(IL-2)、白细胞介素-6(IL-6)和VEGF水平,采用Sperman相关性分析血清IL-2、IL-6与VEGF的相关性。结果观察组和对照组受试者的血清IL-2[(3.47±0.85)μg/L vs(0.96±0.56)μg/L]、IL-6[(223.78±26.54)ng/L vs(117.02±14.37)ng/L]、VEGF[(225.16±30.96)ng/L vs(136.71±20.18)ng/L]水平比较,观察组明显高于对照组,差异均有统计学意义(P<0.05);观察组患者中,Ⅲ级患者的血清IL-2、IL-6和VEGF水平明显高于Ⅱ级,Ⅳ级患者的血清IL-2、IL-6和VEGF水平明显高于Ⅲ级,差异均有统计学意义(P<0.05);Sperman相关性分析结果显示,膝骨关节炎患者血清IL-2和IL-6与VEGF呈显著正相关(r=0.386、0.369,P<0.05)。结论炎性因子IL-2、IL-6可能参与了膝骨关节炎的发生和发展,而且与血管内皮因子之间可能存在一定的关系,进而影响新生血管形成。

Objective To observe and explore the relationship between serum inflammatory factors IL-2,IL-6 and vascular endothelial growth factor(VEGF)in patients with knee osteoarthritis.Methods A total of 36 patients with knee osteoarthritis admitted to the Department of Orthopedics,Nanhai Hospital Affiliated to Southern Medical University from January 2015 to January 2017 were selected as the observation group.Among them,there were 13 cases of Kellgren-Lawrence gradeⅡ,14 cases of gradeⅢ,an d 9 cases of gradeⅣ.In addition,36 healthy subjects for physical examination during the same period were selected as the control group.Serum levels of interleukin-2(IL-2),interleukin-6(IL-6),and VEGF were detected and compared between the two groups.The correlation between serum IL-2、IL-6 and VEGF was analyzed by Sperman correlation.Results The serum IL-2,IL-6,VEGF levels were(3.47±0.85)μg/L,(223.78±26.54)ng/L,(225.16±30.96)ng/L in the observation group,which were significantly higher than(0.96±0.56)μg/L,(117.02±14.37)ng/L,(136.71±20.18)ng/L in the control group(P<0.05).In the observation group,the serum IL-2,IL-6,and VEGF levels of patients with gradeⅢwere significantly higher than those of gradeⅡ,and the levels of serum IL-2,IL-6,and VEGF in patients with gradeⅣwere significantly higher than those of gradeⅢ,with statistically significant differences(P<0.05).Sperman correlation analysis showed that serum IL-2 and IL-6 of patients with knee osteoarthritis were significantly positively correlated with VEGF(r=0.386,0.369,P<0.05).Conclusion The inflammatory factor IL-2,IL-6 may be involved in the occurrence and development of knee osteoarthritis,and they may have a certain relationship with VEGF,which may affect the formation of neovascularization.