双相情感障碍躁狂发作患者病情严重程度与尿酸水平相关性分析

Correlations of disease severity and uric acid levels in patients with bipolar disorder

目的探讨双相情感障碍躁狂发作患者治疗前后杨氏躁狂评分(Young mania rating scale,YMRS)与尿酸水平的变化,探讨尿酸在双相情感障碍躁狂发作患者发病及康复中的重要意义。方法选取中山市第三人民医院2018年1月—2019年1月住院的50例双相情感障碍躁狂发作患者为研究对象。所有入组患者均采取常规的情感稳定剂(碳酸锂缓释片或丙戊酸钠缓释片)单用或联合第二代新型抗精神病药物进行治疗,根据临床症状严重程度调整药物的使用剂量,实验观察周期为8 w。患者出现锥体外系不良反应时可以使用抗胆碱能药,睡眠障碍可适当合并使用小剂量苯二氮[艹卓]类药。所有研究对象入院后均给予本院饭堂的普通饮食,入院第二天早晨7:30抽取空腹肘静脉血检测尿酸水平,入院前两天由规范化培训的医师对研究对象进行YMRS,并做好记录。对所有数据进行统计学处理。结果双相情感障碍躁狂发作患者YMRS分数治疗后较治疗前降低,且差异具有统计学意义(P<0.05)。双相情感障碍躁狂发作患者尿酸值治疗后较治疗前降低,且差异具有统计学意义(P<0.05)。双相情感障碍躁狂发作患者治疗前YMRS分数与治疗前尿酸值无显著相关(P>0.05)。双相情感障碍躁狂发作患者治疗后YMRS分数与治疗后尿酸值无显著相关(P>0.05)。双相情感障碍躁狂发作患者YMRS分数与尿酸值减分率无显著相关(P>0.05)。结论双相情感障碍躁狂发作患者尿酸值治疗后会降低,但是,它与YMRS分数相关性不大。

Objective To analyze the changes of scores by Young Mania Rating Scale(YMRS)and serum uric acid levels in bipolar manic patients before and after treatment so as to explore the significance of uric acid in the manic episode and rehabilitation of bipolar affective disorder.Methods Fifty patients with manic episode of bipolar disorder hospitalized in Zhongshan Third People’s Hospital from January 2018 to January 2019 were selected as the subjects.All the patients were given the common diet in the dining hall of the hospital after admission.The fasting elbow venous blood was taken at 7:30 in the morning the next day after admission for detection of uric acid level.Two days before admission,the trained doctors scored the subjects with Yang’s mania and made records.All data were statistically recorded.Results The YMRS scores of the patients were significantly decreased after treatment(P<0.05).The uric acid value levels after treatment were statistically significantly lower than those before treatment(P<0.05).There was no significant correlation between YMRS score and uric acid value levels before treatment(P>0.05),so it was with the correlation after treatment(P>0.05).Conclusion The uric acid value of patients with bipolar disorder at manic episode will decrease after treatment,but it has little correlation with YMRS score.