达夫反应法合成2,4,6-三羟基苯-1,3,5-三甲醛反应条件研究

Studies on Reaction Conditions for the Synthesis of Triformylphloroglucinol by Duff Reaction

2,4,6-三羟基苯-1,3,5-三甲醛是合成共价有机框架材料和超分子结构的重要中间体,在合成中有很多应用。经达夫反应合成2,4,6-三羟基苯-1,3,5-三甲醛具有操作简单、产物易分离等优点。本文通过对酸性介质、反应温度、反应时间、水解试剂等因素对目标化合物产率的影响,确定了合成2,4,6-三羟基苯-1,3,5-三甲醛的最佳反应条件。

Triformylphloroglucinol is an important intermediate in the synthesis of covalent organic framework materials and supramolecular structures.The synthesis of triformylphloroglucinol with Duff reaction methods has the advantages of simple operation and easy separation.The optimum reaction conditions for synthesis of triformylphloroglucinol were studied.The effects of acidic medium,reaction temperature,reaction time and other factors on the yield of the target compound were discussed in this paper.