甲泼尼龙冲击治疗结节性硬化症合并婴幼儿痉挛症的效果及不良反应

Efficacy and adverse reactions of methylprednisolone pulse therapy for tuberous sclerosis complicated with infantile spasm

目的探讨甲泼尼龙冲击治疗结节性硬化症(TSC)合并婴幼儿痉挛症的效果及不良反应。方法抽取2016年8月至2020年8月周口市妇幼保健院收治的60例TSC合并婴幼儿痉挛症患儿作为研究对象,按照不同治疗方案将患儿分为对照组和研究组,每组30例。对照组采用泼尼松联合常规抗癫痫治疗,研究组在常规抗癫痫治疗基础上给予甲泼尼龙冲击治疗。治疗8周后比较两组患儿用药起效时间、总有效率、住院时间、不良反应发生率。结果研究组用药起效时间为(6.9±2.4)h,住院时间为(24.4±3.6)d,不良反应发生率为3.33%,均低于对照组的(13.1±2.7)h、(29.3±5.3)d、20.00%,差异有统计学意义(P<0.05);研究组总有效率(93.33%)高于对照组(73.33%),差异有统计学意义(P<0.05)。结论 TSC合并婴幼儿痉挛症患儿采用甲泼尼龙冲击治疗可迅速改善痉挛症状,纠正水电解质和代谢紊乱现象,缩短住院时间。而且用药方便,短期用药的不良反应少。

Objective To investigate the clinical effect and adverse effects of methylprednisolone shock therapy in children with tuberous scleros(TSC)and infantile spasticity.Methods Sixty cases of children with TSC and infantile spasticity were admitted to Zhoukou Maternal and Child Health Care Hospital from August 2016 to August 2020 as research object.The children were divided into control group and study group according to different treatment options,30 cases in each groups.The control group was treated with prednisone combined with routine antiepileptic therapy,and the study group was treated with methylprednisolone shock on the basis of routine antiepileptic therapy.After treatment of 8 weeks,the effect time of medication,total effective rate,hospitalization time and adverse reaction rate of the two groups were compared.Results The onset time of medication in the study group was(6.9±2.4)hours,the hospital stay was(24.4±3.6)days,and the incidence of adverse reactions was 3.33%,which were lower than those of the control group(13.1±2.7)hours and(29.3±5.3)hours,20.00%,the differences were significant(P<0.05);the total effective rate in the study group(93.33%)was significantly higher than that in the control group(73.33%),the difference was statistically significant(P<0.05).Conclusions Methylprednisolone shock therapy in the treatment of children with TSC and infantile spasticity can improve the spasmodic symptoms quickly,correct water electrolyte and metabolic disorders,shorten the hospitalization time.Moreover,it is convenient to use and has less adverse reactions in short-term medication.