定坤丹预处理对卵巢低反应患者卵巢储备功能及体外受精-胚胎移植结局的影响

Effects of Dingkundan pretreatment on ovarian reserve function and outcome ofin vitro fertilization-embryo transfer in patients with poor ovarian response

目的探讨定坤丹预处理对卵巢低反应(POR)患者卵巢储备功能及体外受精-胚胎移植(IVF-ET)结局的影响。方法选取2018年1月至2019年10月在本院妇产科生殖中心接受IVF-ET治疗的220例POR患者为研究对象,随机将其分为研究组(行定坤丹预处理)和对照组(未行预处理),各110例。比较两组预处理前、后的卵巢储备功能指标及IVF-ET周期治疗指标。结果研究组预处理后FSH水平低于预处理前及对照组,AMH水平高于预处理前及对照组,AFC多于预处理前及对照组,差异具有统计学意义(P<0.05)。研究组获卵数多于对照组,受精率IVF-ET周期取消率低于对照组,高于对照组,差异具有统计学意义(P<0.05);两组Gn总量、优质胚胎率、胚胎种植率、临床妊娠率比较,差异无统计学意义(P>0.05)。结论采用定坤丹预处理可改善POR患者卵巢储备功能,降低IVF-ET周期取消率,为临床结局改善提供新思路。

Objective To investigate the effect of Dingkundan pretreatment on ovarian reserve function and outcome of in vitro fertilization-embryo transfer(IVF-ET)in patients with poor ovarian response(POR).Methods A total of 220 POR patients who received IVF-ET treatment in the reproductive medical center of obstetrics and gynaecology department of our hospital from January 2018 to October 2019 were selected as the research objects and randomly divided into study group(treated with Dingkundan pretreatment)and control group(not given pretreatment),with 110 cases in each group.The ovarian reserve function indexes before and after pretreatment and IVF-ET cycle treatment indexes of the two groups were compared.Results The FSH level of the study group after pretreatment were lower than that before pretreatment and in the control group,the AMH level was higher than that before pretreatment and in the control group,the AFC were more than that before pretreatment and in the control group,and the differences were statistically significant(P<0.05).The number of retrieved ova of the study group was more than that of the control group,the fertilization rate was higher than that of the control group,IVF-ET cycle cancellation rate was lower than that of the control group,and the differences were statistically significant(P<0.05);there were no significant differences in total Gn volume,high-quality embryo rate,embryo implantation rate and clinical pregnancy rate between the two groups(P>0.05).Conclusion Pretreatment with Dingkundan can improve ovarian reserve function of POR patients,reduce the IVF-ET cycle cancellation rate,and provide new ideas for improving clinical outcomes.