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植物磺基转移酶研究进展

Research progress on plant sulfotransferases
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摘要 磺基转移酶(SOT)能催化磺酸基团(SO3-)从通用供体3′-磷酸腺苷-5′-磷酰硫酸转移到外源化合物、激素、蛋白质等底物的羟基或氨基上,这一过程被称为磺化。SOT具有高度保守的结构域,广泛存在于真细菌和真核生物中,参与生物体的多种代谢活动,如解毒、激素调节和药物代谢等。在植物中,磺化反应在调节生长发育和适应逆境等方面起着重要作用。本文结合国内外关于SOT的报道,综述了植物SOT的来源、底物特异性、结构和生物学功能,并对植物SOT的功能挖掘及应用前景进行了展望。 Sulfonation is a common modification found in eubacteria and eukaryotes. This modification is mediated by the enzymes, sulfotransferases(SOTs), which catalyze the transfer of a sulfuryl group(SO3-) from the universal donor 3′-phosphoadenosine 5′-phosphosulfate to the hydroxyl group or amino group of various substrates, including exogenous compounds, hormones, proteins and so on. SOTs are widely involved in various metabolic activities like detoxification, hormone regulation and drug metabolism in animals including human. Likewise, SOTs are believed to play an important role in plant growth, development and adaptation to stress. In this article, the origin, substrate specificity, structure and biological functions of plant SOTs are reviewed, and functional characterization and potential applications of these important enzymes are prospected.
作者 王亚琴 林淑敏 孙磊 詹若挺 徐晖 WANG Yaqin;LIN Shumin;SUN Lei;ZHAN Ruoting;XU Hui(Research Center of Chinese Herbal Resource Science and Engineering,Guangzhou University of Chinese Medicine,Key Laboratory of Chinese Medicinal Resource from Lingnan(Guangzhou University of Chinese Medicine),Ministry of Education,Joint Laboratory of National Engineering Research Center for the Pharmaceutics of Traditional Chinese Medicines,Guangzhou 510006,China)
出处 《植物生理学报》 CAS CSCD 北大核心 2020年第12期2550-2562,共13页 Plant Physiology Journal
基金 广东省省级乡村振兴战略(农业科技创新及推广体系建设)专项-广东省现代南药产业技术体系创新团队(2019KJ148)。
关键词 磺基转移酶 磺化 3′-磷酸腺苷-5′-磷酰硫酸 底物特异性 生物学功能 sulfotransferase sulfonation 3′-phosphoadenosine 5′-phosphosulfate substrate specificity biological function
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