摘要
FOXP3+调节性T细胞(FOXP3+Treg)是一类能够发挥免疫抑制等调节作用的T细胞亚群,是维持正常人体免疫稳态的关键。近期越来越多的研究揭示了FOXP3+Treg细胞在各类临床疾病的病理过程中所发挥的作用及其分子机制,这为研发针对FOXP+Treg细胞的免疫疗法奠定了基础。该综述将首先对FOXP3+Treg细胞的发育及其基本功能进行概述,并重点阐述近年来有关Treg细胞在传染性疾病中的生理功能、调控机制及针对FOXP3+Treg细胞治疗的研究新进展,并提出相应展望。
FOXP3^+ regulatory T cell(FOXP3^+ Treg) is a subgroup of T lymphocytes with immunosuppressive effects and plays an essential role in the maintenance of human immune homeostasis. Recently, more and more researches revealed the role of FOXP3^+ Treg in the pathogenic processes of human clinical diseases and its mechanism, which lays the foundation for the immune therapies targeting FOXP3^+ Treg. In this review, the development and function of FOXP3^+ Treg will be summarized at first. Then, we will focus on the recent advances in physiological functions and regulatory mechanisms of FOXP3^+ Treg in major infectious diseases as well as the therapeutic strategies, and look forward to the future development.
作者
严妍
那迪娜·帕尔哈提
车千纪
罗菁
刘鑫男
李斌
YAN Yan;NADINA Paerhati;CHE Qian-Ji;LUO Jing;LIU Xin-Nan;LI Bin(Shanghai Institute of Immunology,Shanghai Jiao Tong University School of Medicine,Shanghai 200025,China)
出处
《生命科学》
CSCD
北大核心
2020年第11期1159-1175,共17页
Chinese Bulletin of Life Sciences
基金
上海交通大学医学院第十三期大学生创新项目(1319003)。
