超氧化物歧化酶1与糖脂代谢异常研究新进展

Research advances of superoxide dismutase 1 in metabolic disorders of glucose and lipids

超氧化物歧化酶1 (SOD1)是生物体内抗氧化酶系的重要成员之一,清除体内超氧阴离子和参与活性氧自由基代谢是其经典功能,迄今已知SOD1基因受多种转录因子调控。近年还发现,SOD1自身可作为转录因子调控氧化应激有关基因的表达,且通过抗氧化作用影响与其相互作用的蛋白质或酶的稳定性和功能。SOD1表达的缺失与糖脂代谢异常存在密切联系,相关生物学机制研究正从以上多方面加以解析。该文将对这些新进展做一综述。

Superoxide dismutase 1(SOD1) is one of the most important members of antioxidant enzymes in organism. Its classical function is to remove superoxide anions and participate in the metabolism of reactive oxygen species, and its gene was regulated by multiple transcription factors. In recent years, SOD1 has been found to act as a transcription factor to regulate the oxidative stress responding genes, and moreover, it has the ability to affect the stability and/or functions of proteins/enzymes that have interactions with it via its antioxidant property. Deficiency of SOD1 expression is closely related to the abnormal metabolism of glucose and lipids. The underlying biological mechanism is being analyzed from the above aspects and the progress will be reviewed hereby.