摘要
目的:观察半夏泻心汤对于2型糖尿病(脾弱胃强证)患者的中医症状、血糖及胰岛β细胞功能的影响。方法:采用随机对照试验观察比较66例患者(治疗组33例,对照组33例)的中医症状、血糖及胰岛β细胞功能在用药前后的变化。治疗组用半夏泻心颗粒剂治疗,对照组用半夏泻心颗粒模拟剂治疗,两组患者均接受糖尿病饮食、运动调整等基础治疗及胰岛素皮下注射。以12周为疗程,评估两组患者在治疗血糖指标(包括空腹血糖、餐后两小时血糖、糖化血红蛋白)及胰岛β细胞功能的变化。结果:两组患者治疗后的中医疗效评价中,治疗组有效率为90.63%,对照组为16.67%,两组相比差异有统计学意义(P<0.05)。血糖指标比较:与治疗前相比,两组治疗后患者的空腹血糖、餐后两小时血糖、糖化血红蛋白较前均有明显下降,差异均有统计学意义(P<0.05);治疗后两组间相比,空腹血糖、餐后两小时血糖、糖化血红蛋白的差异有统计学意义(P<0.05)。胰岛功能方面比较:与治疗前相比,治疗组治疗后胰岛β细胞功能指数、胰岛素抵抗指数明显改善,差异均有统计学意义(P<0.05),对照组治疗后胰岛β细胞功能指数、胰岛素抵抗指数改善不明显,差异不具有统计学意义(P>0.05);与对照组相比,治疗组胰岛β细胞功能指数、胰岛素抵抗指数明显改善,差异有统计学意义(P<0.05)。结论:半夏泻心汤联合皮下胰岛素治疗可改善患者的脾弱胃强证候的相关症状,并可以降低2型糖尿病(脾弱胃强证)患者的血糖指标水平,改善患者的胰岛功能,降低胰岛素抵抗。
objective:To observe the effect of Banxia Xiexin decoction on TCM symptoms,blood glucose and isletβcell function in patients with type 2 diabetes mellitus(Spleen weak Stomach strong syndrome).Methods:A randomized controlled trial was used to observe and compare the changes of TCM symptoms,blood glucose and isletβcell function in 66 patients(33 in the treatment group and 33 in the control group)before and after medication.The treatment group was treated with Banxia Xiexin granule,and the control group was treated with Banxia Xiexin granule analogue.Both groups received basic treatment such as diabetes diet,exercise adjustment and insulin subcutaneous injection.a 12 weeks course of treatment was used to evaluate the changes of blood glucose indicators(including fasting blood glucose,two-hour postprandial blood glucose,glycosylated hemoglobin)and isletβcell function in the two groups.Results:Among the evaluation of TCM efficacy after treatment in the two groups,the effective rate was 90.63%in the treatment group and 16.67%in the control group,and the difference between the two groups was statistically significant(P<0.05).Blood glucose index comparison:compared with before treatment,the fasting blood glucose,two hours after meal blood glucose and glycosylated hemoglobin in the two groups decreased significantly compared with the previous one(P<0.05),and the difference between the two groups after treatment was statistically significant(P<0.05).Comparison of islet function:pancreatic pancreas after treatment in treatment group The cell function index and insulin resistance index of islandβwere significantly improved(P<0.05).After treatment,the isletβcell function index and insulin resistance index were not significantly improved in the control group(0.05).Compared with the control group,the isletβcell function index and insulin resistance index were significantly improved(P<0.05).Conclusion:Banxia Xiexin decoction combined with subcutaneous insulin treatment can improve the related symptoms of Spleen weak Stomach strength syndrome,and can reduce the blood glucose index level of patients with type 2 diabetes mellitus(Spleen weak Stomach strength syndrome),improve the islet function of patients and reduce insulin resistance.
作者
王晶
汪晓敏
王晓平
赵丽
岳仁宋
Wang Jing;Wang Xiaomin;Wang Xiaoping;Zhao Li;Yue Rensong(Longquanyi District Hospital of Traditional Chinese Medicine,Chengdu,610100,China;Chengdu University of Traditional Chinese Medicine Hospital,Chengdu,610075,China)
出处
《成都中医药大学学报》
2021年第1期81-85,共5页
Journal of Chengdu University of Traditional Chinese Medicine
基金
国家自然科学基金项目(81774279)
四川省科技厅重点研发项目(2018SZ0068)。
关键词
半夏泻心汤
2型糖尿病
血糖水平
胰岛Β细胞功能
Banxia xiexin decoction
Type 2 diabetes
Blood glucose levels
Islet beta cell function