v-SNAREs在血小板胞吞胞吐中的作用

Role of v-SNAREs in endocytosis and exocytosis of platelets

胞吞胞吐参与了血小板相关物质的摄取、分泌,在血小板止血、血栓形成等过程中发挥着重要作用。近年来研究发现,囊泡可溶性N-乙基马来酰亚胺敏感因子附着蛋白受体家族(vesicle-soluble NSF attachment protein receptors,v-SNAREs)在哺乳动物细胞中高度保守,尤其在胞吞胞吐中扮演了关键角色,发挥着重要作用。本文就v-SNAREs在血小板病理生理过程中的作用机制,及其对血栓形成、冠心病等相关疾病的影响进行了综述,以期为心血管疾病的防治提供新的视野。

Endocytosis and exocytosis participate in the uptake and secretion of platelet-related substances and play an important role in the process of platelet hemostasis and thrombosis. Recent studies have found that vesicle-soluble NSF attachment protein receptors, v-SNAREs, are highly conserved in mammalian cells, and especially play a key role in endocytosis and exocytosis. This review focuses on the role and mechanism of v-SNAREs in the pathophysiological process of platelets, as well as the effects on thrombosis, coronary heart disease and other related diseases, in order to provide new perspective for the prevention and treatment of cardiovascular diseases.