MiR-20a在肿瘤中相关作用机制的研究进展

Research progress on the mechanism of miR-20a in tumor

MiR-20a是miR-17-92簇家族中的一个非编码RNA,靶向目的mRNA从而发挥转录后基因表达的调控功能,但在不同类型的肿瘤进展中发挥的作用不尽相同,提示miR-20a可能是一种细胞或组织特异性miRNA。近年来,研究人员利用生物信息学方法预测miR-20a的靶基因,并进行蛋白质表达验证,进而判断其所在的肿瘤调控信号通路,将miRNA的研究拓展到肿瘤标志物、耐药研究及预后因子等临床应用上来。本文就miR-20a在多种癌症中的作用机制,及其在临床诊断和应用中的进展作一综述,为肿瘤的分子生物学机制研究提供理论依据。

MiR-20a is a non-coding RNA in the miR-17-92 cluster,and plays a regulatory role in posttranscriptional gene expression by aim to target mRNA.However,miR-20a plays different roles in different types of tum or progression,so it may be a cellular or tissue specific miRNA.In recent years,researchers predicted m iR-20a target genes by bioinform atics m ethods.And determ ined the location of the tum or regulatory signaling pathways by verifing the protein expression.The researches of m iRNA is extended to the clinical application of tum or markers,drug resistance and prognostic factors.This article reviews the mechanism of mir-20a in various cancers and its developm ent in clinical diagnosis and application,and provides theoretical basis for the study of molecular biological mechanism of tumors.