成纤维生长因子21在心力衰竭中的研究进展

Research progress of fibroblast growth factor 21 in heart failure

成纤维生长因子21(fibroblast growth factor 21, FGF21)作为一种参与多种病理生理过程的物质能量代谢调节因子,主要参与机体血糖、血脂的调节。FGF21也参与多种心血管疾病的病理生理调节过程,但其在心力衰竭中的研究较少,随着研究的不断深入,发现FGF21对心力衰竭的发生、发展过程具有保护作用,具体调节过程及作用机制尚不明确。本文主要探讨FGF21与心力衰竭的关系及其在心力衰竭中的可能作用机制。

Fibroblast growth factor 21(FGF21),as a regulator of material and energy metabolism involved in a variety of pathophysiological processes,is mainly involved in the regulation of blood glucose and blood lipids.It has been found that FGF21 is also involved in the pathophysiological regulation of a variety of cardiovascular diseases,but there are few studies focus on heart failure.With the deepening of research,FGF21 was found having a protective effect on the occurrence and development of heart failure,but the specific regulation process and mechanism are not clear.This paper mainly discusses the relationship between FGF21 and heart failure and its possible mechanism in heart failure.