血脂指标与胎盘生长因子联合检测对子痫前期的诊断价值

The diagnostic value of combined detection of blood lipid indexes and placental growth factor for preeclampsia

目的探讨血脂指标联合胎盘生长因子(PLGF)检测对子痫前期(PE)的诊断价值。方法选择2018年1月至2019年1月该院收治的PE患者121例为研究对象,按照《妇产科学》第八版的诊断标准将其分为轻度PE组73例和重度PE组48例。另选取同期在该院体检的健康妊娠女性113例为对照组。检测各组三酰甘油(TG)、总胆固醇(TC)、低密度脂蛋白(LDL)、高密度脂蛋白(HDL)、PLGF水平,计算LDL/HDL。采用Logistic回归分析血脂指标对PE发生的影响。采用受试者工作特征曲线(ROC曲线)分析血脂指标、PLGF单独与联合检测诊断PE的效能。结果与对照组比较,轻度PE组和重度PE组的TG、TC、LDL及LDL/HDL水平明显升高,PLGF水平明显下降,差异均有统计学意义(P<0.05)。Logistic回归分析结果显示,TG、TC、LDL、LDL/HDL是PE发生的危险因素(P<0.05)。ROC曲线分析结果显示,TG、TC、LDL、HDL、LDL/HDL与PLGF联合检测诊断PE的曲线下面积最大,为0.9345,灵敏度为83.10%,特异度为82.77%。结论PE患者血脂水平明显升高,而PLGF水平明显降低,血脂指标与PLGF联合检测对PE具有一定的诊断价值。

Objective To explore the diagnostic value of blood lipid indexes combined with placental growth factor(PLGF)in the diagnosis of preeclampsia(PE).Methods A total of 121 cases of PE patients admitted to the hospital from January 2018 to January 2019 were selected as the research objects,and they were divided into mild PE group(73 cases)and severe PE group(48 cases)according to the diagnostic criteria of the Eighth Edition"Obstetrics and Gynecology".Another 113 healthy pregnant women in the hospital were selected as control group.The levels of triglyceride(TG),total cholesterol(TC),low density lipoprotein(LDL),high density lipoprotein(HDL)and PLGF were detected,and LDL/HDL was calculated.Logistic regression was used to analyze the effect of blood lipid indexes on PE.The receiver operating characteristic curve(ROC curve)was used to analyze the efficacy of blood lipid indexes,PLGF alone and combined detection in the diagnosis of PE.Results Compared with control group,the levels of TG,TC,LDL and LDL/HDL in mild PE group and severe PE group significantly increased,and the PLGF level significantly decreased,the differences were statistically significant(P<0.05).Logistic regression analysis showed that TG,TC,LDL,LDL/HDL were risk factors for PE(P<0.05).ROC curve analysis results showed that the combined detection of TG,TC,LDL,HDL,LDL/HDL and PLGF had the largest area under the curve for the diagnosis of PE,which was 0.9345,the sensitivity was 83.10%,and the specificity was 82.77%.Conclusion The blood lipid level of PE patients significantly increases,while the PLGF level significantly reduces.The combine detection of blood lipid indexes and PLGF has certain diagnostic value for PE.