蒙古族药抗动脉粥样硬化作用机制的研究进展

Research Progress on Anti-atherosclerosis Mechanism of Mongolian Medicine

动脉粥样硬化是威胁人类健康的常见多发疾病之一,如何有效的抑制动脉粥样硬化、延长患者生存时间及提高生活质量已成为当今医学领域中亟待解决的重要问题之一。蒙古族医药学(简称"蒙医药学")历史悠久,是我国传统医学的重要组成部分,具有鲜明的民族特色,是在吸收藏族医学、印度医学部分理论及中医学有关知识,逐步形成和发展起来的。它具有毒性低、结构多样等诸多优点,然而,蒙药防治动脉粥样硬化的作用机制尚未完全明晰并影响了蒙医药的进一步推广应用。本文对蒙药相关的研究成果进行了收集、整理、归纳和分析总结,从抗炎、降血脂、抗氧化应激、保护血管内皮细胞、抑制血管平滑肌细胞增殖迁移等多个方面对蒙药抗动脉粥样硬化的作用机制进行了综述,以期对其进一步深入研究提供一些参考。

Atherosclerosis is one of the most common diseases that threaten human health. How to effectively inhibit atherosclerosis,extend the survival time and improve the quality of life has become one of the most urgent issues to be solved clinically. Mongolian medicine, with a long history of managing human diseases,is an important part in traditional Chinese medicine(TCM)and has distinct ethnic characteristics. It has been gradually formed and developed by absorbing some theories of Tibetan medicine,Indian medicine and relevant knowledge of TCM. Mongolian medicine has many advantages,including but not limited to,low toxicity and diverse structure. However, the action mechanism of Mongolian medicine in preventing and managing atherosclerosis has yet to be fully clarified,which has been a major obstacle for further promotion and application of Mongolian medicine in clinical settings. In this review,the up-to-date research findings on Mongolian medicine were collected,analyzed and summarized,and the anti-atherogenic action mechanism of Mongolian medicine were reviewed from the aspects of anti-inflammatory,lipid-lowering,anti-oxidative stress,vascular endothelial cell protection,and inhibition of vascular smooth muscle cell proliferation and migration.