急性秋水仙碱中毒患者的救治经验分享

Experience sharing on treatment of an acute colchicine poisoning patient

秋水仙碱又称秋水仙素,临床上主要用于治疗急性痛风发作、慢性痛风急性发作等疾病,但该药毒性大(剧毒类),且治疗剂量与中毒剂量非常接近,中毒后无特效解毒药物,患者早期临床表现缺乏特异性,给临床诊断和治疗带来一定的难度与挑战,无形中增加了药物中毒致死的概率。到目前为止,秋水仙碱中毒病例均以散发报道,2020年9月1日松桃苗族自治县人民医院收治1例急性秋水仙碱中毒患者,是目前为止权威医学期刊能检索到中毒时间最长的1例,经治疗患者于9月29日痊愈出院,本文报告了该病例的诊治体会。

Colchicine is mainly used in the treatment of acute gout attack,acute attack of chronic gout and other diseases in clinic.But the drug has high toxicity(highly toxic),the therapeutic dose is very close to the toxic dose,and there is no special effect after poisoning drug detoxification.The clinical manifestations of early patients after poisoning are not specific,which brings some difficulties and challenges in clinical diagnosis and treatment,and virtually increases the probability of death from drug poisoning.The drug poisoning is still sporadic reports.On September 1,2020,a patient with acute colchicine poisoning was admitted to People's Hospital of Songtao Miao Autonomous County.This patient is the one with the longest poisoning time that can be retrieved by authoritative medical journals.After treatment,the patient was cured and discharged.This article reported the experience of diagnosis and treatment.