芪红汤联合比索洛尔治疗冠心病合并慢性心力衰竭临床研究

Clinical Study on Qihong Tang Combined with Bisoprolol for Coronary Heart Disease Complicated with Chronic Heart Failure

目的:观察芪红汤联合比索洛尔治疗冠心病合并慢性心力衰竭的临床疗效。方法:将106例冠心病合并慢性心力衰竭患者随机分为对照组和观察组,各53例。对照组给予比索洛尔治疗,观察组给予芪红汤联合比索洛尔方治疗,2组疗程均为2个月。评估2组临床疗效,比较患者左室射血分数(LVEF)、左室舒张末期内径(LVEDd)、左室收缩末期内径(LVESd)、血浆超敏C-反应蛋白(hs-CRP)、氨基末端脑钠肽前体(NT-proBNP)等相关指标的变化。结果:观察组总有效率为88.67%,高于对照组的73.58%(P<0.05)。治疗后,2组LVEF值均较治疗前升高(P<0.05),LVEDd、LVESd值较治疗前降低(P<0.05);且观察组各项指标改善均较对照组更显著(P<0.05)。治疗后,2组血浆hs-CRP、NT-proBNP水平均较治疗前降低(P<0.05);且观察组hs-CRP、NT-proBNP水平均低于对照组(P<0.05)。2组治疗期间血尿常规、肝肾功能未见异常,无治疗相关的不良反应发生。结论:芪红汤联合比索洛尔方治疗冠心病合并慢性心力衰竭效果显著,能改善患者的心功能,调节血浆hs-CRP、NT-proBNP水平,用药安全可靠。

Objective:To observe the clinical effect of Qihong tang combined with bisoprolol for coronary heart disease complicated with chronic heart failure.Methods:A total of 106 cases of patients with coronary heart disease complicated with chronic heart failure were randomly divided into the control group and the observation group,53 cases in each group.The control group was treated with bisoprolol,and the observation group was treated with Qihong tang combined with bisoprolol.Both groups were treated for two months.The clinical effect in the two groups was evaluated;the changes in the related indexes such as left ventricular ejection fraction(LVEF),left ventricular end diastolic diameter(LVEDd),left ventricular end systolic diameter(LVESd),hypersensitive C-reactive protein(HS-CRP)in plasma and N-terminal pro-brain natriuretic peptide(NT-proBNP)were compared.Results:The total effective rate was 88.67%in the observation group,higher than that of73.58%in the control group(P<0.05).After treatment,LVEF values in the two groups were increased when compared with those before treatment(P<0.05),and the values of LVEDd and LVESd were decreased(P<0.05);the improvement of the above indexes in the observation group was more significant than that in the control group(P<0.05).After treatment,the levels of plasma hs-CRP and NT-proBNP in the two groups were decreased when compared with those before treatment(P<0.05),and the above levels in the observation group were lower than those in the control group(P<0.05).During treatment,there was no abnormality in blood and urine routine as well as liver and kidney function,and no treatment-related adverse reactions in the two groups.Conclusion:The therapy of Qihong tang combined with bisoprolol has significant effect in treating coronary heart disease complicated with chronic heart failure,which can improve the heart function of patients and regulate the levels of plasma hs-CRP and NT-proBNP,with safe and reliable medication.