干扰素γ诱导蛋白10和巨噬细胞集落刺激因子在子痫前期患者血清中的表达及其意义被引量：3

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摘要目的探讨干扰素γ诱导蛋白10(IP-10)和巨噬细胞集落刺激因子(MCSF)在子痫前期患者血清中表达及其意义。方法选择182例子痫前期患者(观察组)和200例正常妊娠孕妇(对照组),分别进行血清IP-10和MCSF水平检测,分析血清IP-10、MCSF水平与子痫前期分型和病情的相关性。结果观察组血清IP-10、MCSF水平高于对照组(P<0.05),晚发型血清IP-10、MCSF水平高于早发型(P<0.05),重度子痫高于中度子痫和轻度子痫患者(P<0.05)。Logistic回归方程分析血清IP-10、MCSF是患中重度子痫前期危险因素(P<0.05)。结论子痫前期患者血清IP-10、MCSF水平与其病情严重程度明显相关。水平升高可能与过度炎症反应和抑制新生血管形成有关。

作者陈芳肖海望黄余良张群锋

机构地区湖南省衡阳市南华大学附属第二医院妇产科

出处《中国妇产科临床杂志》 CSCD 2021年第1期66-67,共2页 Chinese Journal of Clinical Obstetrics and Gynecology

关键词干扰素γ诱导蛋白10 粒细胞集落刺激因子子痫前期

分类号 R714.244 [医药卫生—妇产科学]

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参考文献5

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