冷冻联合5-氨基酮戊酸光动力疗法治疗皮肤癌的疗效观察

Efficacy of freezing combined with ALA-PDT therapy for skin cancer

目的探讨冷冻联合5-氨基酮戊酸光动力疗法(ALA-PDT)治疗皮肤癌的效果。方法选取2014年1月至2019年12月间陕西省安康市人民医院收治的60例皮肤癌患者,根据治疗方法不同进行分组,其中采用ALA-PDT疗法治疗的30例患者纳入对照组,采用冷冻联合ALA-PDT疗法治疗的30例患者纳入观察组,比较两组患者的治疗总有效率、疼痛评分、手术创伤面积、不良反应发生率及外观总满意率。结果观察组患者的治疗有效率为96.7%,高于对照组患者的73.3%,差异有统计学意义(P<0.05)。观察组患者的疼痛评分为(4.12±1.03)分,高于对照组患者的(3.45±0.86)分,手术创伤面积(1.26±0.04)cm^(2),低于对照组患者的(1.39±0.05)cm^(2),差异均有统计学意义(均P<0.05)。两组患者不良反应发生率比较,差异无统计学意义(P>0.05)。观察组患者的外观总满意率为93.3%,高于对照组的66.7%,差异有统计学意义(P<0.05)。结论冷冻联合ALA-PDT疗法治疗皮肤癌临床治疗效果较好,手术创伤面积较小,患者对外观的满意度较高,但疼痛评分较高,临床上可以综合考虑选择合适的治疗方法。

Objective To investigate the efficacy of freezing combined with 5-aminolevulinic acid photodynamic therapy(ALA-PDT)in the treatment of skin cancer.Methods A total of 60 patients with skin cancer admitted to Ankang People’s Hospital from January 2014 to December 2019 were selected as the study subjects.They were divided into an observation group and a control group based on the treatment they received.Thirty patients receiving freezing combined with ALA-PDT were included in the observation group and 30 patients receiving ALA-PDT therapy were included in the control group.The overall treatment efficiency,pain score,surgical trauma area,incidence of adverse reactions and overall satisfaction with the appearance were compared between the two groups.Results The overall effective rate was 96.7%in the observation group which was statistically significant higher than 73.3%of the control group(P<0.05).The pain score was 4.12±1.03 in the observation group which was significantly higher than 3.45±0.86 of the control group(P<0.05).The area of surgical wound was 1.36±0.04 cm^(2) for the observation group which was significantly lower than 1.39±0.05 cm^(2) of the control group(P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups(P>0.05).The overall satisfaction rate was 93.3%in the observation group,which was significantly higher than 66.67%in the control group(P<0.05).Conclusion Freezing combined with ALA-PDT therapy showed high efficacy in the treatment of skin cancer with small area of surgical trauma and high patient satisfaction with the appearance in spite of the high pain score.Clinically,appropriate treatment should be chosen before comprehensive consideration.