神经介入联合丁苯酚氯化钠注射液治疗缺血性脑血管疾病的近、远期临床效果及对神经功能的改善作用

The short-term and long-term clinical efficacies of neural intervention combined with butylphenol and sodium chloride injection in the treatment of ischemic cerebrovascular diseases and the improvement of neurological function

目的观察神经介入联合丁苯酚氯化钠注射液治疗缺血性脑血管疾病的近、远期临床效果及对神经功能的改善作用。方法回顾性选取2018年11月至2019年11月我院缺血性脑血管疾病患者100例,依据治疗方法分为神经介入联合丁苯酚氯化钠注射液治疗组(丁苯酚氯化钠注射液组,n=50)和神经介入联合0.9%氯化钠注射液治疗组(0.9%氯化钠注射液组,n=50),统计分析两组患者血管再通情况、Vd水平、Vs水平、NO水平、ET-1水平、vWF水平、NIHSS评分、mRS评分、ADL评分、并发症发生情况、死亡情况。结果丁苯酚氯化钠注射液组血管再通率为84.00%(42/50),高于0.9%氯化钠注射液组的72.00%(36/50)(P<0.05)。两组患者治疗后Vd、Vs水平均低于治疗前,且丁苯酚氯化钠注射液组低于0.9%氯化钠注射液组(P<0.05);丁苯酚氯化钠注射液组患者治疗后ET-1水平显著高于治疗前(P<0.05),但治疗前后血浆NO、vWF水平比较,差异无统计学意义(P>0.05),0.9%氯化钠注射液组患者治疗后NO水平显著低于治疗前(P<0.05),ET-1水平显著高于治疗前(P<0.05),但治疗前后vWF水平比较,差异无统计学意义(P>0.05),治疗前两组患者NO、ET-1、vWF水平比较,差异无统计学意义(P>0.05),治疗后丁苯酚氯化钠注射液组患者NO水平显著高于0.9%氯化钠注射液组(P<0.05),血浆ET-1、vWF水平显著低于0.9%氯化钠注射液组(P<0.05)。两组治疗后NIHSS评分、mRS评分、ADL评分均低于治疗前,且丁苯酚氯化钠注射液组低于0.9%氯化钠注射液组(P<0.05)。丁苯酚氯化钠注射液组并发症总发生率和死亡率分别为6.00%(3/50)、0,低于0.9%氯化钠注射液组的14.00%(7/50)和6.00%(3/50),差异有统计学意义(P<0.05)。结论神经介入联合丁苯酚氯化钠注射液治疗缺血性脑血管疾病较0.9%氯化钠注射液治疗的近、远期临床效果好,能进一步有效改善患者的神经功能。

Objective To observe the short-term and long-term clinical efficacies of neural intervention combined with butylphenol and sodium chloride injection in the treatment of ischemic cerebrovascular diseases and the improvement of neurological function.Methods A total of 100 patients with ischemic cerebrovascular disease admitted to our hospital from November 2018 to November 2019 were retrospectively selected and divided into the neural intervention combined with butylphenol and sodium chloride injection treatment group(n=50,the butylphenol and sodium chloride injection treatment group)and the neural intervention combined with 0.9%sodium chloride injection treatment group(n=50,the 0.9%sodium chloride injection treatment group)according to the treatment method.The vascular recanalization,Vd level,Vs level,NO level,ET-1 level,vWF level,NIHSS score,mRS score,ADL score,incidence of complications and mortality rate of the patients in the two groups were statistically analyzed.Results The recanalization rate was 84.00%(42/50)in the butylphenol sodium chloride injection group,which was higher than 72.00%(36/50)in the 0.9%sodium chloride injection group(P<0.05).The levels of Vd and Vs in the two groups after treatment were lower than those before treatment,and those in the butylphenol sodium chloride injection group were lower than those in the 0.9%sodium chloride injection group(P<0.05).The level of ET-1 in butylphenol sodium chloride injection group after treatment was significantly higher than that before treatment(P<0.05).However,there was no significant difference in plasma NO and vWF levels before and after treatment(P>0.05).The level of NO in 0.9%sodium chloride injection group was significantly lower than that before treatment(P<0.05),ET-1 level was significantly higher than that before treatment(P<0.05).But there was no significant difference in vWF level before and after treatment(P>0.05).There was no significant difference in the levels of NO,ET-1 and vWF between the two groups before treatment(P>0.05).After treatment,the level of NO in butylphenol sodium chloride injection group was significantly higher than that in 0.9%sodium chloride injection group(P<0.05).Plasma ET-1 and vWF levels were significantly lower than those in 0.9%sodium chloride injection group(P<0.05).The NIHSS score,mRS score and ADL score of the two groups after treatment were lower than those before treatment,and the score of the butylphenol sodium chloride injection group was lower than that of the 0.9%sodium chloride injection group(P<0.05).The total incidence of complications and mortality in the butylphenol sodium chloride injection group were 6.00%(3/50)and 0,respectively,which were lower than 14.00%(7/50)and 6.00%(3/50)in the 0.9%sodium chloride injection group,the difference was statistically significant(P<0.05).Conclusion The short-term and long-term clinical efficacies of neural intervention combined with butylphenol and sodium chloride injection in the treatment of ischemic cerebrovascular diseases were better than those of the 0.9%sodium chloride injection treatment group,and it could further effectively improve the neurological function of patients.