当归明目汤联合康柏西普治疗湿性老年黄斑变性临床疗效观察

Observation on The Effects of Danggui Mingmu Decoction Combined with Conbercept in The Treatment of Wet age-related Senile Macular Degeneration

目的:评估当归明目汤联合抗血管内皮生长因子(VEGF)融合蛋白类康柏西普治疗湿性年龄相关性黄斑变性(wAMD)患者的疗效及安全性。方法:考察该方案的临床疗效,将检查确诊为wAMD患者60例60眼纳入研究,其中当归明目汤联合康柏西普研究组(研究组)30例30眼,单纯用康柏西普玻璃体腔注射对照组(对照组)30例30眼,分别于治疗前与治疗后1周、1个月、3个月、6个月检查2组患者的视力、黄斑中心凹厚度以及脉络膜新生血管情况,并对2组患者的康复情况进行比较。结果:与治疗前比较,研究组接受联合治疗6个月后最佳矫正视力平均值由(0.09±0.05)升至(0.34±0.11),差异有统计学意义;黄斑中心凹厚度值由(427.63±45.54)μm下降至(217.67±15.90)μm,差异有统计学意义;与对照组比较,研究组治疗6个月后视力提高更明显,黄斑中心凹厚度更趋于正常,差异均有统计学意义;对肝肾指标检测,研究组及对照组的肝肾指标在治疗前后均在正常范围值内波动,且各组间差异不存在显著性。结论:当归明目汤联合抗VEGF药物康柏西普治疗wAMD,可显著提高患者视力,降低黄斑中心凹厚度,减少并发症,且疗效优于单纯抗VEGF治疗。

Objective:To evaluate the efficacy and safety of Danggui Mingmu Decoction combined with the anti-vascular endothelial growth factor fusion protein Conbercept in the treatment of wet age-related senile macular degeneration(wAMD)patients.Methods:To investigate the clinical efficacy of this therapeutic regimen,60 patients diagnosed with wAMD were recruited in the study,including 30 cases in the research group which were administrated with Danggui Mingmu Decoction combined with anti-VEGF Conbercept,and 30 cases in the control group,which were injected intravitreally with Conbercept alone.Changes in visual acuity,macular foveal thickness,and CNV were examined at 1 week,1,3,and 6 months after treatment,and the rehabilitation status of the two groups was compared.Results:After treatment,the average corrected visual acuity of the study group after 6 months of combined treatment increased from(0.09±0.05)to(0.34±0.11),and the difference was statistically significant;From(427.63±45.54)μm to(217.67±15.90)μm,the difference was statistically significant.Compared with the control group,the visual acuity of the study group was significantly improved after 6 months of treatment,and the macular foveal thickness became more standard,and the differences were statistically significant.For the detection of liver and kidney indicators,both the study group and the control group fluctuated within the normal range,and there was no significant difference between groups.Conclusion:DangguiMingmu Decoction combined with the anti-VEGF drug Conbercept can significantly improve patients'vision,reduce the thickness of the macular fovea,reduce complications,and the effect is better than that of anti-VEGF therapy alone.