复元活血汤联合湿润烧伤膏治疗糖尿病足临床研究

Clinical Study on Fuyuan Huoxue Tang Combined with Shirun Shaoshang Ointmentfor Diabetic Foot

目的:观察复元活血汤联合湿润烧伤膏对糖尿病足患者创面愈合情况、足背动脉血流动力学及下肢功能的影响。方法:将88例糖尿病足患者按随机数字表法分为研究组和对照组,各44例。对照组给予湿润烧伤膏治疗,研究组在对照组的基础上联合复元活血汤治疗。比较2组临床疗效、创面愈合情况、足背动脉血流动力学及下肢神经传导功能。结果:研究组总有效率为88.64%,对照组为61.36%,2组比较,差异有统计学意义(P<0.05)。治疗后,2组创面面积、创面pH均较治疗前降低(P<0.05),经皮氧分压较治疗前升高(P<0.05);且研究组上述各项指标改善较对照组更显著(P<0.05)。治疗后,2组足背动脉血管内径、血流量较治疗前增加(P<0.05),峰值流速较治疗前降低(P<0.05);且研究组上述指标改善较对照组更显著(P<0.05)。治疗后,2组腓总神经感觉传导速度、胫神经运动传导速度均较治疗前升高(P<0.05);且研究组腓总神经感觉传导速度、胫神经运动传导速度均高于对照组(P<0.05)。结论:复元活血汤联合湿润烧伤膏能够有效缓解糖尿病足患者的临床症状,促进创面愈合,纠正足背动脉血流动力学异常,改善下肢神经传导功能。

Objective:To observe the effect of Fuyuan Huoxue tang combined with Shirun Shaoshang ointment on wound healing,the hemodynamics of dorsal artery of foot,and lower limb function of patients with diabetic foot.Methods:A total of 88 cases of patients with diabetic foot were selected as the study subjects and were divided into the study group and the control group according to the random number table method,44 cases in each group.The control group was treated with Shirun Shaoshang ointment,and the study group was additionally treated with Fuyuan Huoxue tang based on the treatment of the control group.The clinical effect,wound healing,the hemodynamics of dorsal artery of foot,and nerve conduction function of lower limbs were compared between the two groups.Results:The total effective rate was 88.64%in the study group,and 61.36%in the control group,the difference being significant(P<0.05).After treatment,the area of wound and pH of wound in the two groups were decreased when compared with those before treatment(P<0.05),and transcutaneous oxygen pressure was increased(P<0.05);the improvement of the above indexes in the study group was more significant than that in the control group(P<0.05).After treatment,the diameter and blood flow of dorsal artery of foot in the two groups were increased(P<0.05),and peak velocity was decreased when compared with that before treatment(P<0.05);the improvement of the above indexes in the study group was more significant than that in the control group(P<0.05).After treatment,the sensory conduction velocity of common peroneal nerve and the motor conduction velocity of tibial nerve in the two groups were increased when compared with those before treatment(P<0.05),and the velocity above in the study group was higher than that in the control group(P<0.05).Conclusion:For the patients with diabetic foot,the therapy of Fuyuan Huoxue tang combined with Shirun Shaoshang ointment can effectively relieve their clinical symptoms,promote wound healing,resolve the abnormal hemodynamics of dorsal artery of foot,and improve the nerve conduction function of lower limbs.