早期糖尿病肾病中医体质分布特点及与FBG、Alb、Hb 指标相关性研究

Study on Correlation Between Distribution Features of Chinese Medicine Constitutionsof Patients with Early Diabetic Nephropathy and Indexes of FBG,Alb and Hb

目的:探讨早期糖尿病肾病(DN)中医体质分布特点及与空腹血糖(FBG)、白蛋白(Alb)和血红蛋白(Hb)等指标关系。方法:将早期DN患者300例作为早期DN组,另选取未发DN的糖尿病患者300例作为对照组,观察早期DN组患者体质分布特点,测定FBG、Alb、Hb等指标并比较。结果:2组平和质、气虚质、阳虚质、血瘀质分布比较,差异有统计学意义(P<0.05)。早期DN组FBG水平高于对照组,Hb水平低于对照组,Alb水平高于对照组,差异有统计学意义(P<0.05)。2组各类并发症发生频率比较,早期DN组高于对照组,差异有统计学意义(P<0.05)。以体质作为危险因素,对早期DN患者进行非条件Logisitc回归分析,结果得出,阴虚质、气虚质、血瘀质及平和质是早期DN的危险因素,其中以血瘀质对患者并发早期DN的影响最大。结论:早期DN患者,中医体质分布以气虚质、阴虚质和血瘀质为主,FBG、Alb、Hb等指标与普通糖尿病患者比较差异显著,且易发各类并发症,及早明确并制定针对性管理措施,对提升患者预后质量意义重大。

Objective:To discuss the relationship between distribution features of Chinese medicine constitutions of patients with early diabetic nephropathy(DN)and indexes of fasting blood glucose(FBG),albumin(Alb)and hemoglobin(Hb).Methods:A total of 300 cases of patients with early DN were enrolled as the early DN group.Another 300 diabetic patients without DN were selected as the control group.The distribution features of constitutions in the early DN group were observed.The indexes of FBG,Alb and Hb were measured and compared.Results:When compared the distribution of moderate constitution,qi deficiency constitution,yang deficiency constitution,and blood stasis constitution between the two groups,there was significance in the difference(P<0.05).Compared with those in the control group,in the early DN group,the level of FBG and Alb were higher,and the level of Hb was lower,the difference being significant(P<0.05).The frequency of complications in the early DN group was higher than that in the control group,the difference being significant(P<0.05).According to the non-conditional logistic regression analysis with constitutions as a risk factor for early DN patients,it was found that yin deficiency constitution,qi deficiency constitution,blood stasis constitution and moderate constitution were the risk factors for early DN,and blood stasis constitution contributed most to the occurrence of early DN in diabetic patients.Conclusion:In patients with early DN,the distribution of Chinese medicine constitutions is dominated by qi deficiency constitution,yin deficiency constitution and blood stasis constitution.Their levels of FBG,Alb,Hb and other indexes are significantly different from those of ordinary diabetic patients,and are prone to various complications.It is of great significance to identify and formulate targeted management measures as soon as possible to improve the prognosis quality of patients.