摘要
肺炎球菌是人类最常见的细菌性病原微生物之一,是引起肺炎、脑膜炎、中耳炎、鼻窦炎和菌血症等的主要病原体。肺炎球菌感染在全球范围内导致较高的发病率和死亡率,且在诊断、治疗和预防方面存在许多挑战。针对肺炎球菌相关疾病,目前已上市的肺炎球菌多糖疫苗存在制备成本高、血清型覆盖率有限、血清型替代等局限性,因此,急需开发广谱的新型肺炎球菌疫苗。其中溶血素作为潜在的候选蛋白抗原,在新型肺炎球菌疫苗开发中受到广泛关注。本文对以溶血素为抗原蛋白的新型肺炎球菌疫苗的研究进展作一综述。
Streptococcus pneumoniae is one of the most common bacterial pathogens,which is the main cause of pneumonia,meningitis,otitis media,sinusitis and bacteremia. Pneumococcal infection has caused a high incidence rate and mortality worldwide,which faces many challenges in diagnosis,treatment and prevention. Polysaccharide vaccines targeting S. pneumoniae-related diseases have some limitations,such as high preparation cost,limited serotype coverage,and serotype replacement. Therefore,it is urgent to develop novel broad-spectrum S. pneumoniae vaccines. As a potential candidate protein antigen,pneumolysin has been widely used in the development of novel S. pneumoniae vaccines. This paper reviews the progress in research on novel S. pneumoniae vaccines using pneumolysin as antigen protein.
作者
刘宗华(综述)
薛巍(审校)
LIU Zong-hua;XUE Wei(Department of Biomedical Engineering,School of Life Science and Technology,Jinan University,Guangzhou 510632,Guangdong Province,China)
出处
《中国生物制品学杂志》
CAS
CSCD
北大核心
2021年第2期220-224,共5页
Chinese Journal of Biologicals
基金
国家自然科学基金面上项目(31870943)。
关键词
肺炎球菌疫苗
溶血素
佐剂
抗原递送系统
Streptococcus pneumonia
Pneumolysin
Adjuvant
Antigen delivery system