疏肝理脾方联合灌肠治疗慢性非特异性溃疡性结肠炎肝郁脾虚证临床研究

Clinical Study on Shugan Lipi Prescription Combined with Enema for Chronic Non-Specific Ulcerative Colitis with Liver Depression and Spleen Deficiency Syndrome

目的:观察疏肝理脾方联合灌肠治疗慢性非特异性溃疡性结肠炎肝郁脾虚证的疗效及对炎症因子、血小板、血沉水平的影响。方法:将肝郁脾虚证慢性非特异性溃疡性结肠炎患者86例,按随机数字表法分为对照组和观察组2组,各43例。2组均采用常规治疗方法,对照组给予口服美沙拉秦缓释片,观察组在此基础上给予煎服疏肝理脾方联合灌肠进行治疗,2组疗程均为8周。观察疗效并比较分析对患者血清炎症因子、血小板(BPC)、血沉(ESR)水平的影响。结果:治疗后,2组炎症因子均较前改善,观察组血清白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)水平均低于对照组(P<0.05),血清白细胞介素-10(IL-10)水平高于对照组(P<0.05)。治疗后,2组BPC、ESR水平较前改善,观察组BPC、ESR水平均下降且低于对照组(P<0.05)。观察组总有效率为90.70%,高于对照组74.42%(χ^(2)=3.957,P=0.047<0.05)。结论:采用疏肝理脾方联合灌肠治疗肝郁脾虚证慢性非特异性溃疡性结肠炎患者,可抑制炎症反应,改善凝血机制,治疗效果佳。

Objective:To observe the curative effect of Shugan Lipi prescription combined with enema for chronic non-specific ulcerative colitis with liver depression and spleen deficiency syndrome,and its effect on the levels of inflammatory factors, platelet, and erythrocyte sedimentation rate. Methods:A total of 86 cases of patients with chronic non-specific ulcerative colitis with liver depression and spleen deficiency syndrome were divided into the control group and the observation group according to the random number table method, 43 cases in each group. Both groups were given routine treatment methods. The control group was additionally given oral administration of mesalazine sustained-release tablets;the observation group was additionally treated with oral administration of Shugan Lipi prescription combined with enema based on the treatment on the control group. Both groups were treated for eight weeks. The curative effect was observed. The effect on the levels of inflammatory factors, blood platelet count(BPC), and erythrocyte sedimentation rate(ESR) in serum were compared and analyzed. Results:After treatment, the inflammatory factors in the two groups were improved when compared with those before, and the levels of interleukin-6(IL-6) and tumor necrosis factor(TNF-α) in serum in the observation group were lower than those in the control group(P<0.05);the level of IL-10 in serum was higher than that in the control group(P<0.05). After treatment,the levels of BPC and ESR in the two groups were improved when compared with those before,and the two levels in the observation group were decreased,lower than those in the control group(P<0.05). The total effective rate was 90.70% in the observation group, higher than that of 74.42% in the control group(χ^(2)=3.957,P=0.047<0.05). Conclusion:For patients with chronic non-specific ulcerative colitis with liver depression and spleen deficiency syndrome,Shugan Lipi prescription combined with enema can inhibit inflammatory responses,and improve the coagulation mechanism,with good curative effect.