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复方甘草酸苷胶囊联合常规西药治疗儿童特应性湿疹临床研究 被引量:5

Clinical Study on Compound Glycyrrhizin Capsules Combined with Routine Western Medicine for Children with Atopic Eczema
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摘要 目的:观察复方甘草酸苷胶囊联合常规西药治疗儿童特应性湿疹的临床疗效与安全性。方法:将90例脾虚湿蕴证患儿按随机数字表法分为观察组和对照组各45例。2组患儿均予氯雷他定片与糠酸莫米松乳膏治疗,并给予润肤剂、健康教育、沐浴指导等基础处理措施。观察组加予复方甘草酸苷胶囊治疗。2组疗程均为3个月。治疗前、治疗3个月后评价特应性皮炎积分(SCORAD)、儿童皮肤病生活质量指数(CDLQI)和研究者整体评价法(IGA)评分,监测血常规、肝功能、肾功能和心电图情况。记录治疗期间发生的不良反应,比较2组的临床疗效。结果:治疗后,观察组临床疗效优于对照组(P<0.05)。2组SCORAD皮损面积、皮损严重程度、瘙痒和影响睡眠程度评分及总分均较治疗前降低(P<0.01),观察组各维度评分及总分均低于对照组(P<0.01)。2组CDLQI及IGA评分均较治疗前下降(P<0.01),观察组CDLQI及IGA评分均低于对照组(P<0.01)。2组患儿在观察期间均无严重不良反应发生。结论:复方甘草酸苷胶囊联合常规西药治疗儿童特应性湿疹可进一步缓解患儿的临床症状,提高患儿的生活质量,临床疗效显著。 Objective:To observe the clinical effect and safety of compound glycyrrhizin capsules combined with routine western medicine for children with atopic eczema. Methods:A total of 90 cases of children with atopic eczema with spleen deficiency with dampness encumbrance syndrome were divided into the observation group and the control group according to random number table method,45 cases in each group. Both groups were treated with loratadine tablets and mometasone furoate cream, as well as basic treatment measures such as emollients, health education, and bathing guidance. The observation group was additionally treated with compound glycyrrhizin capsules. Both groups were treated for three months. Before treatment and after three-month treatment,the scores of Scoring Atopicdermatitis(SCORAD),Children’s Dermatology Life Quality Index(CDLQI),and Investigator’s Global Assessment(IGA) were evaluated;the blood routine,the liver function, the kidney function, and electrocardiogram were monitored. During treatment, the incidence of adverse reactions was recorded. The clinical effect was compared between the two groups. Results:After treatment, the clinical effect in the observation group was better than that in the control group(P<0.05). The area and severity degree of skin lesions,the scores of itch and insomnia,as well as the total scores in the two groups were decreased when compared with those before treatment(P<0.01);each score and the total score in the observation group were lower than those in the control group(P<0.01). The scores of CDLQI and IGA in the two groups were decreased when compared with those before treatment(P<0.01),and the two scores in the observation group were lower than those in the control group(P<0.01). There was no severe adverse reaction happened in the two groups during observation period. Conclusion:The therapy of compound glycyrrhizin capsules combined with routine western medicine has significant clinical effect in treating children with atopic eczema,which can further relieve their clinical symptoms and improve life quality.
作者 丁娟 DING Juan
出处 《新中医》 CAS 2021年第2期74-77,共4页 New Chinese Medicine
关键词 特应性湿疹 儿童 脾虚湿蕴证 复方甘草酸苷胶囊 生活质量 特应性皮炎积分 Atopic eczema Children Spleen deficiency with dampness encumbrance syndrome Compound glycyrrhizin capsules Quality of life Scoring Atopicdermatitis
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