PHBV纳米纤维的静电纺丝及在生物医用领域的研究进展

Research Progress of Preparation of Poly (3-hydroxybutyrate-co-3-hydroxyvalerate) Nanofibers Based on Electrospinning and Its Applications in Biomedicine Fields

聚(3-羟基丁酸酯-3-羟基戊酸酯)(PHBV)纳米纤维具有高比表面积、高孔隙率、生物相容性、生物降解性等优点,可用作生物医用材料。本文综述了基于静电纺丝法制备的PHBV纳米纤维及其在生物医用领域的研究进展,讨论了PHBV纺丝溶液的溶剂、浓度、外加盐类以及聚合物等对PHBV纳米纤维形貌、结构及性能的影响规律,结合目前PHBV纳米纤维在组织工程和药物运输载体的研究现状,重点概述了其亲水改性、力学性能改善、功能化改性的研究进展。最后,对静电纺丝法制备PHBV纳米纤维存在的一些问题进行分析,并对其未来发展趋势和前景进行展望。

Poly(3-hydroxybutyrate-3-hydroxyvalerate)(PHBV) nanofibers have been attractively used as biomedical materials due to its high specific surface area, high porosity, biocompatibility, and biodegradability. This review summarizes the methods to control the morphology and structure of PHBV electrospun nanofibers nanofiber by adjusting the solvent, concentration, additional salts and polymers of PHBV electrospinning solution. Based on the recently research of PHBV nanofibers in tissue engineering and drug delivery carriers, the improvement of hydrophilicity and mechanical properties PHBV nanofibers are emphatically introduced. In addition, some problems existing in preparations and applications of electrospun PHBV nanofibers in biomedical field are further proposed. Finally, the development trends and prospects for PHBV nanofibers are forecasted.