趋化因子-10与自身免疫性甲状腺疾病的研究进展

Research Progress of Chemokine-10 in Autoimmune Thyroid Diseases

自身免疫性甲状腺疾病(Autoimmune thyroid disease,AITD)在儿童及青少年中的发病率逐年升高,其发病机制尚不明确。近年来对该病的遗传及免疫学机制进行了大量研究,尤其是趋化因子在AITD发病机制及疾病进展中的作用已成为国内外研究的热点,本文综述了Th1趋化因子CXCL10与AITD的基础科学、动物模型、临床研究等方面的近几年文献,了解CXCL10在该病中的变化及意义,为明确AITD的发病机理,提高儿童AITD诊治水平以及监测病情预后拓宽思路。

The incidence of autoimmune thyroid disease(AITD)in children and adolescents is increasing year by year,but its pathogenesis is unclear.In recent years,A large number of studies have been carried out on the genetic and immunological mechanism of the disease.Especially the role of chemokines in the pathogenesis and progress of disease has become a hot topic at domestic and overseas.This article reviews the literature on the basic science,animal model and clinical research of Th1 chemokine CXCL10 and AITD in recent years,to understand the variation and significance of CXCL10 in this disease,and to broaden the way to clarify the pathogenesis of AITD,improve the level of diagnosis and treatment of AITD in children and monitor the prognosis of the disease.