基于超声弹性定量技术的检测方式对HIV患者颈动脉粥样硬化价值分析

Value analysis of carotid atherosclerosis in HIV patients based on ultrasonic elasticity quantification technique

目的研究基于超声弹性定量技术的检测方式对人类免疫缺陷病毒(HIV)患者颈动脉粥样硬化价值。方法将医院从2017年11月~2020年2月收治的304例新发HIV感染患者记作新发HIV组。另取同期于我院接受体检的志愿者40例记作对照组。再取接受高效抗反转录病毒治疗5年以上的HIV患者40例记HIV治疗组。分别比较三组人员的各项基线(性别、年龄、体质量指数、吸烟、饮酒、收缩压、舒张压)资料,此外,对所有受试者均实施基于超声弹性定量技术的检测,获取相关参数[包括右侧颈动脉内中膜厚度(IMT)、血管直径、血管位移、硬度系数、脉搏波传导速度]进行对比。以SPearman相关性分析明确HIV患者各项超声弹性定量参数的关系。结果新发HIV组、对照组、HIV治疗组在吸烟、饮酒、收缩压、舒张压方面比较均不明显(均P>0.05)。新发HIV组与HIV治疗组血管位移分别为(366.72±91.45)μm、(349.23±87.53)μm,明显低于对照组的(462.35±105.83)μm;且HIV治疗组硬度系数、脉搏波传导速度均高于新发HIV组以及对照组(均P<0.05);三组颈动脉IMT以及血管直径对比均不明显(均P>0.05)。经SPearman相关性分析可得:血管位移与硬度系数、脉搏波传导速度均呈负相关关系,而硬度系数与脉搏波传导速度呈正相关关系(均P<0.05)。结论基于超声弹性定量技术的检测方式早期评估HIV患者颈动脉粥样硬化价值较高,值得临床推广应用。

Objective:To study the value of ultrasonic elasticity quantification technique for carotid atherosclerosis in human immunodeficiency virus(HIV)patients.Methods:304 patients with new HIV infection admitted to the hospital from November 2017 to February 2020 were classified as the new HIV group.In addition,40 volunteers who received physical examination in our hospital during the same period were taken as the control group.In addition,40 HIV patients who had received effective antiretroviral therapy for more than 5 years were enrolled in the HIV treatment group.Respectively to compare the baseline of three groups of people(gender,age,body mass index,smoking,drinking,systolic pressure,diastolic blood pressure),in addition,for all the subjects are based on the technology of ultrasonic elasticity quantitative detection,access to relevant parameters[including the right carotid intima-media thickness(IMT),blood vessel diameter,blood vessels,displacement,hardness coefficient,pulse wave conduction velocity]were compared.SPearman correlation analysis was used to determine the relationship between the quantitative parameters of ultrasound elasticity in HIV patients.Results:Smoking,drinking,systolic blood pressure and diastolic blood pressure were not significant in the newly diagnosed HIV group,the control group and the HIV treatment group(all P>0.05).The vascular displacement of the newly developed HIV group and the treatment group was(366.72±91.45)m and(349.23±87.53)m,respectively,which was significantly lower than that of the control group(462.35±105.83)m.The hardness coefficient and pulse wave conduction velocity of the HIV treatment group were higher than those of the newly diagnosed HIV group and the control group(all P<0.05).The comparison of carotid IMT and vascular diameter was not significant in the three groups(all P>0.05).SPearman correlation analysis showed that vascular displacement was negatively correlated with hardness coefficient and pulse wave conduction velocity,while hardness coefficient was positively correlated with pulse wave conduction velocity(all P<0.05).Conclusion:The early evaluation of carotid atherosclerosis in HIV patients based on ultrasonic elasticity quantitative technology is of high value and is worthy of clinical application.